Vpr and Its Interactions with Cellular Proteins

被引：29

作者：

Planelles, Vicente ^{[1
]}

Benichou, Serge ^{[2
]}

机构：

[1] Univ Utah, Sch Med, Dept Pathol, Div Cell Biol & Immunol, Salt Lake City, UT 84112 USA

[2] CNRS, INSERM, Inst Cochin, Dept Malad Infect,U567,UMR8104, F-75014 Paris, France

来源：

HIV INTERACTIONS WITH HOST CELL PROTEINS | 2009年 / 339卷

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; MITOCHONDRIAL PERMEABILITY TRANSITION; URACIL DNA GLYCOSYLASE; NUCLEAR-PORE COMPLEX; C-TERMINAL DOMAIN; HIV-1 PREINTEGRATION COMPLEX; CUL4-DDB1 UBIQUITIN LIGASE; VIVO MUTATION-RATE; TYPE-1; VPR; CYCLE ARREST;

D O I：

10.1007/978-3-642-02175-6_9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Like most viral regulatory proteins, HIV-1 Vpr and homologous proteins from primate lentiviruses are small and multifunctional. They are associated with a plethora of effects and functions, including induction of cell cycle arrest in the G(2) phase, induction of apoptosis, trans activation, enhancement of the fidelity of reverse transcription, and nuclear import of viral DNA in macrophages and other nondividing cells. This review focuses on the cellular proteins that have been reported to interact with Vpr and their significance with respect to the known functions and effects of Vpr on cells and on viral replication.

引用

页码：177 / 200

页数：24

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