Synthesis of chiral 3-substituted phthalides via rhodium(I)-catalyzed crossed alkyne cyclotrimerisation

被引：0
|
作者：
Witulski, B [1 ]
Zimmermann, A [1 ]
机构：
[1] Univ Kaiserslautern, Fachbereich Chem, D-67663 Kaiserslautern, Germany
来源：
SYNLETT | 2002年 / 11期
关键词：
phthalides; alkyne cyclotrimerisation; Wilkinson's catalyst; propargylic alcohols; (S)-3-n-butylphthalide;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
3-Substituted phthalides were synthesized for the first time by crossed alkyne cyclotrimerisations with Wilkinson's catalyst. Esterification of propiolic acids with chiral propargylic alcohols by either the DCC/DMAP or the Mitsunobu method allows the synthesis of either enantiomeric form of diyne esters, that are used in crossed alkyne cyclotrimerisations with acetylene to provide 3-substituted phthalides in both enantiomeric forms.
引用
收藏
页码：1855 / 1859
页数：5
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