Interaction of human phagocytes with pigmentless Aspergillus conidia

被引：93

作者：

Jahn, B

Boukhallouk, F

Lotz, J

Langfelder, K

Wanner, G

Brakhage, AA

机构：

[1] Johannes Gutenberg Univ Mainz, Inst Med Microbiol & Hyg, D-55101 Mainz, Germany

[2] Johannes Gutenberg Univ Mainz Klinikums, Inst Klin Chem & Lab Med, D-55101 Mainz, Germany

[3] Tech Univ Darmstadt, Inst Mikrobiol & Genet, D-64287 Darmstadt, Germany

[4] Univ Munich, Inst Bot, D-80638 Munich, Germany

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 06期

关键词：

D O I：

10.1128/IAI.68.6.3736-3739.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A defect in the pksP gene of Aspergillus fumigatus is associated with the loss of conidial pigmentation, a profound change of the conidial surface structure, and reduced virulence. The structural change of the conidial surface structure was not observed in similar A. nidulans wA mutants. Our data indicate that the pigment of both species is important for scavenging reactive oxygen species and for protection of conidia against oxidative damage.

引用

页码：3736 / 3739

页数：4

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