Influence of pravastatin on carotid artery structure and function in dyslipidemic HIV-infected patients receiving antiretroviral therapy

被引：27
作者：
Boccara, Franck [1 ]
Simon, Tabassome
Lacombe, Karine
Cohen, Ariel
Laloux, Brigitte
Bozec, Erwan
Durant, Stephanie
Girard, Pierre-Marie
Laurent, Stephane
Boutouyrie, Pierre
机构：
[1] Univ Paris 05, Dept Pharmacol, Fac Med, INSERM 652,Hop Europeen Georges Pompidou, Paris, France
[2] Univ Paris 06, Assistance Publ Hop Paris, Dept Cardiol, St Antoine Univ Hosp, Paris, France
[3] Univ Paris 06, Assistance Publ Hop Paris, Dept Pharmacol, St Antoine Univ Hosp, Paris, France
[4] Univ Paris 06, Assistance Publ Hop Paris, URC, EST,Dept Infect Dis,St Antoine Univ Hosp, Paris, France
来源：
AIDS | 2006年 / 20卷 / 18期
关键词：
D O I：
10.1097/QAD.0b013e32801120e3
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Forty-two pravastatin-treated HIV-positive patients and 42 sex, age, and smoking status-matched hypercholesterolemic HIV-positive patients not under lipid-lowering treatment were compared for differences in intima-media thickness (IMT) of the common carotid artery (CCA) and aortic stiffness. Pravastatin had no influence on carotid artery structure and function, or aortic stiffness. Age and body mass index were independent determinants of IMT of the CCA. Mean arterial pressure, age, duration of HIV infection and protease inhibitor exposure determined aortic stiffness.
引用
收藏
页码：2395 / 2398
页数：4
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