Specificity and sensitivity of the Self-assessment of Negative Symptoms (SNS) in patients with schizophrenia

被引:22
作者
Dollfus, Sonia [1 ,2 ,3 ]
Delouche, Camille [1 ]
Hervochon, Cecile [4 ]
Mach, Cyril [1 ]
Bourgeois, Valerie [4 ]
Rotharmel, Maud [4 ,5 ]
Trehout, Maxime [1 ,2 ,3 ]
Vandevelde, Anais [1 ,2 ,3 ]
Guillin, Olivier [4 ,5 ,6 ]
Morello, Remy [7 ]
机构
[1] CHU Caen, Serv Psychiat, F-14000 Caen, France
[2] Normandie Univ, UINICAEN, ISTS, GIP Cyceron, F-14000 Caen, France
[3] Normandie Univ, UINICAEN, UFR Med, F-14000 Caen, France
[4] Ctr Hosp Rouvray, F-76300 Rouen, France
[5] CHU Charles Nicolle, F-76000 Rouen, France
[6] Univ Med, INSERM, U1079, F-76000 Rouen, France
[7] CHU Caen, Unite Biostat & Rech Clin, F-14000 Caen, France
关键词
Schizophrenia; Self-assessment; Negative symptoms; SNS; Sensitivity; Specificity; CLINICAL-ASSESSMENT INTERVIEW; HIGH-RISK; PSYCHOSIS; VALIDITY; VERSION; SCALE; DEPRESSION; VALIDATION;
D O I
10.1016/j.schres.2019.07.012
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objectives: Negative symptoms can be present at any stage of schizophrenia but their evaluation remains challenging. Self-evaluations may be particularly useful in screening negative symptoms quickly and effectively. The purpose of this study was to determine the sensitivity, the specificity, and the threshold beyond which the negative symptoms are considered pathological in a comparative study between patients with schizophrenia and healthy subjects using the Self-assessment of Negative Symptoms (SNS). Methods: One hundred and nine patients with schizophrenia and schizoaffective disorders (DSM-5) and 99 healthy controls were included and evaluated with the SNS. AUROC analyses were performed to assess the discriminant performance of the SNS scale for screening negative symptoms in the whole sample of patients but also in 2 patient sub-samples without high scores of depression or negative symptoms. Results: The SNS (AUROC = 0.942 +/- 0.046; p < 0.001) appears to be an appropriate screening tool for distinguishing between SZ and HC with a threshold value of 7. and the sensitivity and specificity were 92.7% (95CI = [86.1-96.8]) and 85.9% (95CI = [77.4-92.1]) respectively. A threshold at 7 was also observed in the samples without patients with high level of depressive or negative symptoms. Conclusion: These results indicate that SNS might be a valuable tool for screening negative symptoms in clinical practice regardless the level of depressive and negative symptoms. Further studies using SNS in subjects at high risk for psychosis or with a first psychotic episode would be useful in the detection of negative symptoms. (C) 2019 Elsevier B.V. All rights reserved.
引用
收藏
页码:51 / 55
页数:5
相关论文
共 29 条
[1]   ASSESSING DEPRESSION IN SCHIZOPHRENIA - THE CALGARY DEPRESSION SCALE [J].
ADDINGTON, D ;
ADDINGTON, J ;
MATICKATYNDALE, E .
BRITISH JOURNAL OF PSYCHIATRY, 1993, 163 :39-44
[2]   Cross-cultural Validation of the 5-Factor Structure of Negative Symptoms in Schizophrenia [J].
Ahmed, Anthony O. ;
Kirkpatrick, Brian ;
Galderisi, Silvana ;
Mucci, Armida ;
Rossi, Alessandro ;
Bertolino, Alessandro ;
Rocca, Paola ;
Maj, Mario ;
Kaiser, Stefan ;
Bischof, Martin ;
Hartmann-Riemer, Matthias N. ;
Kirschner, Matthias ;
Schneider, Karoline ;
Garcia-Portilla, Maria Paz ;
Mane, Anna ;
Bernardo, Miguel ;
Fernandez-Egea, Emilio ;
Cui Jiefeng ;
Jing, Yao ;
Tan Shuping ;
Gold, James M. ;
Allen, Daniel N. ;
Strauss, Gregory P. .
SCHIZOPHRENIA BULLETIN, 2019, 45 (02) :305-314
[3]  
[Anonymous], 1989, BJPsych
[4]   Comparison of Beck Depression Inventories-IA and -II in psychiatric outpatients [J].
Beck, AT ;
Steer, RA ;
Ball, R ;
Ranieri, WF .
JOURNAL OF PERSONALITY ASSESSMENT, 1996, 67 (03) :588-597
[5]   Persistent negative symptoms in first-episode schizophrenia: A prospective three-year follow-up study [J].
Chang, W. C. ;
Hui, Christy L. M. ;
Tang, Jennifer Y. M. ;
Wong, Gloria H. Y. ;
Lam, May M. L. ;
Chan, Sherry K. W. ;
Chen, Eric Y. H. .
SCHIZOPHRENIA RESEARCH, 2011, 133 (1-3) :22-28
[6]   The subjective quality of life in deficit and nondeficit schizophrenic patients [J].
Delamillieure, P ;
Ochoa-Torres, D ;
Vasse, T ;
Brazo, P ;
Gourevitch, R ;
Langlois, S ;
Assouly-Besse, F ;
Van Der Elst, A ;
Morello, R ;
Guelfi, J ;
Petit, M ;
Dollfus, S .
EUROPEAN PSYCHIATRY, 2005, 20 (04) :346-348
[7]   Self-Evaluation of Negative Symptoms: A Novel Tool to Assess Negative Symptoms [J].
Dollfus, Sonia ;
Mach, Cyril ;
Morello, Remy .
SCHIZOPHRENIA BULLETIN, 2016, 42 (03) :571-578
[8]   Persistent negative symptoms in first episode patients with schizophrenia: Results from the European First Episode Schizophrenia Trial [J].
Galderisi, Silvana ;
Mucci, Armida ;
Bitter, Istvan ;
Libiger, Jan ;
Bucci, Paola ;
Fleischhacker, W. Wolfgang ;
Kahn, Rene S. .
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2013, 23 (03) :196-204
[9]   The diagnostic odds ratio: a single indicator of test performance [J].
Glas, AS ;
Lijmer, JG ;
Prins, MH ;
Bonsel, GJ ;
Bossuyt, PMM .
JOURNAL OF CLINICAL EPIDEMIOLOGY, 2003, 56 (11) :1129-1135
[10]   Negative symptoms in youths with psychosis spectrum features: Complementary scales in relation to neurocognitive performance and function [J].
Gur, Raquel E. ;
March, Mary ;
Calkins, Monica E. ;
Weittenhiller, Lauren ;
Wolf, Daniel H. ;
Turetsky, Bruce I. ;
Gur, Ruben C. .
SCHIZOPHRENIA RESEARCH, 2015, 166 (1-3) :322-327