Nickel-Catalyzed Amination of Aryl Chlorides with Amides

被引：22
作者：
Li, Jinpeng [1 ]
Huang, Changyu [1 ]
Wen, Daheng [1 ]
Zheng, Qingshu [1 ]
Tu, Bo [1 ]
Tu, Tao [1 ,2 ,3 ,4 ]
机构：
[1] Fudan Univ, Dept Chem, Shanghai Key Lab Mol Catalysis & Innovat Mat, Shanghai 200438, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
[3] Zhengzhou Univ, Green Catalysis Ctr, Zhengzhou 450001, Peoples R China
[4] Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Peoples R China
来源：
ORGANIC LETTERS | 2021年 / 23卷 / 03期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
D O I：
10.1021/acs.orglett.0c03836
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A nickel-catalyzed amination of aryl chlorides with diverse amides via C-N bond cleavage has been realized under mild conditions. A broad substrate scope with excellent functional group tolerance at a low catalyst loading makes the protocol powerful for synthesizing various aromatic amines. The aryl chlorides could selectively couple to the amino fragments rather than the carbonyl moieties of amides. Our protocol complements the conventional amination of aryl chlorides and expands the usage of inactive amides.
引用
收藏
页码：687 / 691
页数：5
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