The COVID-Kidney Controversy: Can SARS-CoV-2 Cause Direct Rena Infection?

被引：11

作者：

Lau, Wei Ling ^{[1
]}

Zuckerman, Jonathan E. ^{[2
]}

Gupta, Ajay ^{[1
]}

Kalantar-Zadeh, Kamyar ^{[1
]}

机构：

[1] Univ Calif Irvine, Sch Med, Div Nephrol Hypertens & Kidney Transplantat, Orange, CA 92868 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

来源：

NEPHRON | 2021年 / 145卷 / 03期

关键词：

COVID-19; SARS-CoV-2; Kidney pathology; Immunohistochemistry; Ribonucleic acid;

D O I：

10.1159/000513789

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Context: Determining whether SARS-CoV-2 causes direct infection of the kidneys is challenging due to limitations in imaging and molecular tools. Subject of Review: A growing number of conflicting kidney biopsy and autopsy reports highlight this controversial issue. Second Opinion: Based on the collective evidence, therapies that improve hemodynamic stability and oxygenation, or dampen complement activation, are likely to ameliorate acute kidney injury in COVID-19. At this time, whether inhibition of viral infection and replication directly modulates kidney damage is inconclusive. (C) 2021 S. Karger AG, Basel

引用

页码：275 / 279

页数：5

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