DNA origami mediated precise fabrication of nanostructures in multi scales

Y Atomic and atom-like manufacturing has thoroughly investigated by researchers from physical science and materials science in recent years. Several novel properties which cannot be explained by classical theories can be revealed by materials in the case of the manufacturing scale progressing from micron and nanometer to atomic level gradually, so that researchers from related fields have shown the constant pursuit of ultimate manufacturing scales and subversive properties. As an advanced method of precisely manipulating the structural units on a nanoscale, DNA nanotechnology has brought a new insight into nano/atomic manufacturing during its evolution. Meanwhile, the DNA origami technique has proposed the solutions for the accurate fabrication of matters based on its remarkable programmability in design process and might create opportunities for precise construction under more minute scale and more arbitrary shape for multiple matters and materials. In this review, we first briefly summarize the fundamentals, evolutions and several representative researches of DNA origami technique, and then we further summarize some corresponding investigations of nano-fabrications based on the DNA origami structures according to the fabrication strategies. Finally, we put forward some considerations of the potential feasibility in utilizing DNA origami structures for atomic manufacturing and give some prospects for the future development of this field.