Proteomic tools and new insights for the study of B-cell precursor acute lymphoblastic leukemia

被引：3
作者：
Citalan-Madrid, Ali F. [1 ]
Cabral-Pacheco, Griselda A. [1 ,2 ]
Martinez-de-Villarreal, Laura E. [3 ]
Villarreal-Martinez, Laura [4 ]
Ibarra-Ramirez, Marisol [3 ]
Garza-Veloz, Idalia [1 ,2 ]
Cardenas-Vargas, Edith [1 ,2 ,5 ]
Marino-Martinez, Ivan [6 ]
Martinez-Fierro, Margarita L. [1 ,2 ]
机构：
[1] Zacatecas Autonomous Univ, Acad Unit Human Med & Hlth Sci, Mol Med Lab, Zacatecas, Mexico
[2] Zacatecas Autonomous Univ, Acad Unit Human Med & Hlth Sci, Program Doctorate Sci Orientat Mol Med, Zacatecas, Mexico
[3] Univ Autonoma Nuevo Leon, Fac Med, Dept Genet, Monterrey, Mexico
[4] Univ Autonoma Nuevo Leon, Hosp Univ Dr Jose Eleuterio Gonzalez, Hematol Serv, Monterrey, Mexico
[5] Hosp Gen Zacatecas Luz Gonzalez Cosio, Zacatecas, Mexico
[6] Univ Autonoma Nuevo Leon, Fac Med, Dept Patol, Monterrey, Mexico
来源：
HEMATOLOGY | 2019年 / 24卷 / 01期
关键词：
Leukemia; haematological malignancy; proteomics; acute lymphoblastic leukemia; MINIMAL RESIDUAL DISEASE; FLOW-CYTOMETRY; BIOMARKER DISCOVERY; MASS-SPECTROMETRY; PROGNOSTIC BIOMARKERS; ANALYSIS REVEALS; IN-VIVO; CORRELATE; CLASSIFICATION; PROTEINS;
D O I：
10.1080/16078454.2019.1664127
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is a hematological malignancy of immature B-cell precursors, affecting children more often than adults. The etiology of BCP-ALL is still unknown, but environmental factors, sex, race or ethnicity, and genomic alterations influence the development of the disease. Tools based on protein detection, such as flow cytometry, mass spectrometry, mass cytometry and reverse phase protein array, represent an opportunity to investigate BCP-ALL pathogenesis and to identify new biomarkers of disease. This review aims to document the recent advancements with respect to applications of proteomic technologies to study mechanisms of leukemogenesis, how this information could be used in the discovery of biological targets, and finally we describe the challenges of application of proteomic tools for the approach of BCP-ALL.
引用
收藏
页码：637 / 650
页数：14
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