Phosphonamidates are the first phosphorus-based zinc binding motif to show inhibition of ?-class carbonic anhydrases from bacteria, fungi, and protozoa

被引：10

作者：

Alissa, Siham A. ^{[1
]}

Alghulikah, Hanan A. ^{[1
]}

Alothman, Zeid A. ^{[2
]}

Osman, Sameh M. ^{[2
]}

Del Prete, Sonia ^{[3
]}

Capasso, Clemente ^{[3
]}

Nocentini, Alessio ^{[4
]}

Supuran, Claudiu T. ^{[4
]}

机构：

[1] Princess Nourah Bint Abdulrahman Univ, Coll Sci, Chem Dept, POB 84428, Riyadh 11671, Saudi Arabia

[2] King Saud Univ, Coll Sci, Chem Dept, Riyadh, Saudi Arabia

[3] CNR, Ist Biosci & Biorisorse, Naples, Italy

[4] Univ Firenze, Sez Sci Farmaceut & Nutraceut, NEUROFARBA Dept, Florence, Italy

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2020年 / 35卷 / 01期

关键词：

Virulence; resistance; carbonic anhydrase; inhibition; phosphonamidate; selectivity; MALASSEZIA-GLOBOSA; SECONDARY SULFONAMIDES; SELECTIVE INHIBITORS; TARGETING VIRULENCE; N-NITROSULFONAMIDES; ISOZYMES I; DISCOVERY; CHEMOTYPE; CLONING; POTENT;

D O I：

10.1080/14756366.2019.1681987

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A primary strategy to combat antimicrobial resistance is the identification of novel therapeutic targets and anti-infectives with alternative mechanisms of action. The inhibition of the metalloenzymes carbonic anhydrases (CAs, EC 4.2.1.1) from pathogens (bacteria, fungi, and protozoa) was shown to produce an impairment of the microorganism growth and virulence. As phosphonamidates have been recently validated as human ?-CA inhibitors (CAIs) and no phosphorus-based zinc-binding group have been assessed to date against ?-class CAs, herein we report an inhibition study with this class of compounds against ?-CAs from pathogenic bacteria, fungi, and protozoa. Our data suggest that phosphonamidates are among the CAIs with the best selectivity for ?-class over human isozymes, making them interesting leads for the development of new anti-infectives.

引用

页码：59 / 64

页数：6

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