Stereoselective Synthesis of β-Amino Ketones via Direct Mannich-Type Reaction Catalyzed with SO42-/TiO2 and SO42-/Nano TiO2

被引：21
作者：
Samet, Masoud [2 ]
Eftekhari-Sis, Bagher [1 ]
Hashemi, Mohammed M. [2 ]
Farmad, Fateme [2 ]
机构：
[1] Univ Maragheh, Dept Chem, Fac Basic Sci, Maragheh, Iran
[2] Sharif Univ Technol, Dept Chem, Tehran, Iran
来源：
SYNTHETIC COMMUNICATIONS | 2009年 / 39卷 / 24期
关键词：
beta-Amino ketones; Mannich reaction; nano-TiO2; SO42-/TiO2; SOLVENT-FREE CONDITIONS; CONVENIENT SYNTHESIS; FLUOXETINE; ZROCL2-CENTER-DOT-8H(2)O; ISOMERIZATION; AMINOALCOHOL; TOMOXETINE; REDUCTION; INDUCTION; ALDEHYDES;
D O I：
10.1080/00397910902906594
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
At room temperature, SO42-/TiO2 and SO42-/nano-TiO2 efficiently catalyze the direct Mannich-type reaction of varieties of in situ-generated aldimines using aldehydes and anilines with ketones in a three-component reaction under solvent-free conditions. The reaction proceeds rapidly and affords the corresponding beta-amino ketones in good to high yields with good to excellent stereoselectivity. The catalyst can be recycled for subsequent reactions without any appreciable loss of efficiency.
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页码：4441 / 4453
页数：13
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