Co-expression of Epstein-Barr virus latent membrane protein 1, bcl-2, bcl-xL, p21Cip1 and p53 genes in human lymphoepitihelial carcinoma

被引：0
作者：
Kocki, J [1 ]
Jarosz, B
Constantinou, M
Korszen-Pilecka, I
Pilecki, M
Antosz, H
Staroslawska, E
Korobowicz, E
Kaluzewski, B
Wojcierowski, J
机构：
[1] Med Univ, Dept Med Genet, PL-20950 Lublin, Poland
[2] Med Univ, Dept Clin Pathol, PL-20950 Lublin, Poland
[3] Med Univ, Dept Med Genet, PL-91425 Lodz, Poland
[4] Catholic Univ Lublin, Dept Biol Mol, PL-20718 Lublin, Poland
[5] Oncol Ctr Lublin Dist, PL-20090 Lublin, Poland
来源：
BULLETIN OF THE VETERINARY INSTITUTE IN PULAWY | 2002年
关键词：
Epstein-Barr virus; LMP1; gene; bcl-2; bcl-x(L) gene; human lymphoepithelial carcinoma;
D O I：
暂无
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Activation of latent genes of Epstein-Barr virus (EBV) protects human cells from apoptosis and can induce the expression of bcl-2 gene, a survival factor and inhibitor of apoptosis. We used in situ hybridization technique to detect of EBV LMP1, Bcl-2, BCL-X-L, p21(Cip1) and p53 genes expression in paraffin-embedded tissue from patient with a very rare lumphoepithelial carcinoma (undifferentiated carcinomas with lymphoid stroma) of parotid gland. We detected expression of LMP1, bcl-X-L and strong signals from bcl-2, We did not detect signals of p53 and p21(Cip1). We have fixed a potent mechanism of development of a parotid gland carcinoma: EBV infection or/and LMP1 activation --> overexpression of bcl-2 and bcl-X-L --> decreased expression of p53 and p21(Cip1) --> immortalization of cells --> cancer.
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页码：33 / 37
页数：5
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