Molecular Heterogeneity and Evolution in Breast Cancer

被引：12

作者：

Caswell-Jin, Jennifer L. ^{[1
]}

Lorenz, Carina ^{[1
]}

Curtis, Christina ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Med, Div Oncol, Stanford, CA 94305 USA

来源：

ANNUAL REVIEW OF CANCER BIOLOGY, VOL 5, 2021 | 2021年 / 5卷

基金：

美国国家卫生研究院;

关键词：

breast cancer; intratumor heterogeneity; tumor evolution; tumor microenvironment; breast cancer subtypes; NEOADJUVANT CHEMOTHERAPY; GENOMIC CHARACTERIZATION; CHROMATIN ACCESSIBILITY; SUBCELLULAR RESOLUTION; PATHOLOGICAL RESPONSE; PREDICTS RESPONSE; TUMOR EVOLUTION; GENE-EXPRESSION; REVEALS; TISSUE;

D O I：

10.1146/annurev-cancerbio-060220-014137

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer comprises a heterogeneous group of tumor subtypes, whether defined by immunohistochemistry of key proteins, RNA expression profiles, or genetic alterations, and each of these subtypes may benefit from a distinct treatment approach. However, there can be striking heterogeneity within tumors, which may pose challenges to the development of personalized approaches to therapy. Intratumor heterogeneity can be divided into three main categories: genetic, phenotypic, and microenvironmental. Here, we review technologies to interrogate these three categories of heterogeneity in patient samples, as well as the current state of understanding of these categories in breast cancer, from cell to cell, across different regions of the same tumor mass, across treatment, and across metastasis. Efforts to characterize tumor heterogeneity longitudinally will be crucial to the development of personalized oncology for breast cancer.

引用

页码：79 / 94

页数：16

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