Low- and high-dose radioiodine ablation for low-/intermediate-risk differentiated thyroid cancer in China: A large randomized clinical trial

被引：8

作者：

Dong, Ping ^{[1
]}

Wang, Li ^{[2
]}

Qu, Yuan ^{[3
]}

Huang, Rui ^{[1
]}

Li, Lin ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, Dept Nucl Med, Guoxue Alley 37, Chengdu 610041, Peoples R China

[2] Sichuan Univ, West China Hosp, Dept Pancreat Surg, Chengdu, Peoples R China

[3] Tongji Univ, East Hosp, Dept Med Imaging, Shanghai, Peoples R China

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2021年 / 43卷 / 04期

基金：

中国国家自然科学基金;

关键词：

China; differentiated thyroid cancer; prospective study; radioiodine; remnant ablation;

D O I：

10.1002/hed.26594

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background: To determine whether 1.1 GBq radioiodine therapy is as effective as 3.7 GBq for ablation in Chinese patients with differentiated thyroid cancer (DTC). Methods: In this single-center randomized study, we compared the successful radioiodine ablation rates of 1.1 GBq and 3.7 GBq for patients with DTC. Results: At 6-8 months after radioiodine ablation, there were 95 (39%) patients in the 1.1 GBq group and 79 (32%) patients in the 3.7 GBq group with thyroid hormone withdrawal (THW), and ablation success rates were 84% versus 80%, respectively; and 149 (61%) patients in the 1.1 GBq group and 169 (68%) patients in the 3.7 GBq group without THW, and ablation success rates were 89% versus 90%, respectively. In total, the ablation was successful in 412 (87%) of the 474 patients, and it was similar between the two groups. Conclusions: Low-dose radioiodine ablation was as effective as high dose in Chinese DTC patients.

引用

页码：1311 / 1320

页数：10

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