5-HT2a receptor polymorphism gene in bipolar disorder and harm avoidance personality trait

被引：0

作者：

Blairy, S

Massat, I

Staner, L

Le Bon, O

Van Gestel, S

Van Broeckhoven, C

Hilger, C

Hentges, F

Souery, D

Mendlewicz, J

机构：

[1] Free Univ Brussels, Hop Erasme, Dept Psychiat, B-1070 Brussels, Belgium

[2] Hosp Rouffach, FORENAP, Dept Psychiat, Rouffach, France

[3] Free Univ Brussels, Brugmann Hosp, Dept Psychiat, B-1050 Brussels, Belgium

[4] Univ Antwerp VIB, Dept Biochem, B-2020 Antwerp, Belgium

[5] CRP Sante, Luxembourg, Luxembourg

[6] Ctr Hosp Luxembourg, Lab Immunoallergol, Luxembourg, Luxembourg

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS | 2000年 / 96卷 / 03期

关键词：

personality; 5-HT2A; association study; harm avoidance; bipolar disorder;

D O I：

10.1002/1096-8628(20000612)96:3<360::AID-AJMG24>3.0.CO;2-E

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The purpose of this study was to investigate the relationship between bipolar disorder and the harm avoidance personality trait (HA), and the genetic contribution of the polymorphic DNA variation T102C in exon 1 of 5-HTR2a (chromosome 13q14-21) in bipolar disorder and HA personality trait. Forty bipolar patients and 89 normal subjects completed the TPQ questionnaire and were genotyped for 5-HT2a. Bipolar patients scored higher than normal subjects on the HA dimension. However, no contribution of the 5-HTR2a polymorphism on the bipolar disorder or on the HA personality trait emerged. Despite the limited sample size, these results exclude a major effect of the 5-HTR2a polymorphism on bipolar disorder and HA personality trait but not a minor effect. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:360-364, 2000. (C) 2000 Wiley-Liss, Inc.

引用

页码：360 / 364

页数：5

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