De novo design and synthesis of helix-turn-helix structure from short and robust mixed helices derived from C-linked carbo-β-amino acids

被引：29

作者：

Sharma, Gangavaram V. M.

Subash, Velaparthi

Narsimulu, Kongari

Sankar, Ampapathi Ravi

Kunwar, Ajit C.

机构：

[1] Indian Inst Chem Technol, Organ Chem Div 3, Discovery Lab, Hyderabad 500007, Andhra Pradesh, India

[2] Indian Inst Chem Technol, Ctr Nucl Magnet Resonance, Hyderabad 500007, Andhra Pradesh, India

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 48期

关键词：

conformation analysis; foldamers; helical structures; helix-turn-helix motif; peptides;

D O I：

10.1002/anie.200603084

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) In a twist: Tethering of short peptides with robust 10/12-mixed helices, derived from C-linked carbo-β-amino acids, to the turn-inducing motif, β-hGly-D-Pro-Gly-β-hGly, permitted a de novo design of the helix-turn-helix motif in the foldamer domain. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：8207 / 8210

页数：4

共 10 条

[1] Synthesis of new 1,2-dideoxy C-linked carbo-β-amino acids and α/β-peptides with 11/9-helix, helix-turn and helix-turn-helix structures
Adepu, Ramesh
Kanakaraju, Marumudi
Chandramouli, Nagula
Reddy, Purushotham P.
Sharma, Gangavaram V. M.
Sarma, Akella V. S.
Kunwar, Ajit C.
TETRAHEDRON, 2018, 74 (42) : 6095 - 6106
[2] Synthesis of β-Peptides with β-Helices from New C-Linked Carbo-β-Amino Acids: Study on the Impact of Carbohydrate Side Chains
Sharma, Gangavaram V. M.
Rao, Kota Sudhakar
Ravi, Rapolu
Narsimulu, Kongari
Nagendar, Pendem
Chandramouli, Chirutha
Kumar, Singarapu Kiran
Kunwar, Ajit C.
CHEMISTRY-AN ASIAN JOURNAL, 2009, 4 (01) : 181 - 193
[3] The stereoselective synthesis of C-linked 4′-deoxy aza-disaccharides from C-linked carbo-β-amino acids
Sharma, GVM
Pendem, N
Reddy, KR
Krishna, PR
Narsimulu, K
Kunwar, AC
TETRAHEDRON LETTERS, 2004, 45 (48) : 8807 - 8810
[4] 9/11 mixed helices in α/β peptides derived from C-linked carbo-β-amino acid and L-ala repeats
Sharma, GVM
Nagendar, P
Jayaprakash, P
Krishna, PR
Ramakrishna, KVS
Kunwar, AC
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (36) : 5878 - 5882
[5] 12/10- and 11/13-mixed helices in α/γ- and β/γ-hybrid peptides containing C-linked carbo-γ-amino acids with alternating α- and β-amino acids
Sharma, Gangavaram V. M.
Jadhav, Vivekanand B.
Ramakrishna, Kallaganti V. S.
Jayaprakash, Pagadala
Narsimulu, Kongari
Subash, Velaparthi
Kunwar, Ajit C.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (45) : 14657 - 14668
[6] Left-handed helical twists in "mixed peptides derived from alternating C-linked carbo-β3-amino acids and β-hGly units
Sharma, GVM
Reddy, KR
Krishna, PR
Sankar, AR
Jayaprakash, P
Jagannadh, B
Kunwar, AC
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (30) : 3961 - 3965
[7] A left-handed 9-helix in γ-peptides:: Synthesis and conformational studies of oligomers with dipeptide repeats of C-linked carbo-γ4-amino acids and γ-aminobutyric acid
Sharma, Gangavaram V. M.
Jayaprakash, Pagadala
Narsimulu, Kongari
Sankar, Ampapathi Ravi
Reddy, Kondreddy Ravinder
Krishna, Palakodety Radha
Kunwar, Ajit C.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (18) : 2944 - 2947
[8] Synthesis and conformational studies of peptides from new C-linked carbo-β-amino acids (β-Caas) with anomeric methylamino- and difluorophenyl moieties
Sharma, Gangavaram V. M.
Subash, Velaparthi
Reddy, Nelli Yella
Narsimulu, Kongari
Ravi, Rapolu
Jadhav, Vivekanand B.
Murthy, Upadhyayula S. N.
Kishore, Kankipati Hara
Kunwar, Ajit C.
ORGANIC & BIOMOLECULAR CHEMISTRY, 2008, 6 (22) : 4142 - 4156
[9] Synthesis of C-linked carbo-β2-amino acids and β2-peptides: design of new motifs for left-handed 12/10-and 10/12-mixed helices
Sharma, Gangavaram V. M.
Reddy, Nelli Yella
Ravi, Rapolu
Sreenivas, Bommagani
Sridhar, Gattu
Chatterjee, Deepak
Kunwar, Ajit C.
Hofmann, Hans-Joerg
ORGANIC & BIOMOLECULAR CHEMISTRY, 2012, 10 (46) : 9191 - 9203
[10] Theoretical and Experimental Studies on α/ε-Hybrid Peptides: Design of a 14/12-Helix from Peptides with Alternating (S)-C-Linked Carbo-ε-amino Acid [(S)-ε-Caa(x)] and L-Ala
Sharma, Gangavaram V. M.
Babu, Bommagani Shoban
Chatterjee, Deepak
Ramakrishna, Kallaganti V. S.
Kunwar, Ajit C.
Schramm, Peter
Hofmann, Hans-Joerg
JOURNAL OF ORGANIC CHEMISTRY, 2009, 74 (17): : 6703 - 6713

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