Depressive symptoms and risk of liver-related mortality in individuals with hepatitis B virus infection: a cohort study

被引：9

作者：

Cho, In Young ^{[1
]}

Chang, Yoosoo ^{[2
,3
,4
]}

Sung, Eunju ^{[1
,2
]}

Sohn, Won ^{[5
]}

Kang, Jae-Heon ^{[1
]}

Shin, Hocheol ^{[1
,2
]}

Ryu, Seungho ^{[2
,3
,4
]}

机构：

[1] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Family Med, Sch Med, 29 Saemunan Ro, Seoul 03181, South Korea

[2] Sungkyunkwan Univ, Ctr Cohort Studies, Total Healthcare Ctr, Kangbuk Samsung Hosp,Sch Med, Seoul, South Korea

[3] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Occupat & Environm Med, Sch Med, Samsung Main Bldg B2,250 Taepyung Ro 2ga, Seoul 04514, South Korea

[4] Sungkyunkwan Univ, Dept Clin Res Design & Evaluat, SAIHST, Seoul, South Korea

[5] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Div Gastroenterol, Dept Internal Med,Sch Med, Seoul, South Korea

来源：

SCIENTIFIC REPORTS | 2020年 / 10卷 / 01期

关键词：

METABOLIC SYNDROME; HEPATOCELLULAR-CARCINOMA; PHYSICAL-ACTIVITY; IMMUNE-SYSTEM; CANCER-RISK; DISEASE; ASSOCIATION; HEALTH; METAANALYSIS; ANXIETY;

D O I：

10.1038/s41598-020-77886-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The impact of depression on the risk of liver-related mortality in individuals with hepatitis B virus (HBV) infection remains unclear. We examined the association between depression, HBV infection, and liver-related mortality. A total of 342,998 Korean adults who underwent health examinations were followed for up to 7.8 years. Depressive symptoms were defined as a Center for Epidemiologic Studies-Depression score >= 16. Cox proportional hazard models were used to estimate adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs). During 1,836,508 person-years of follow-up, 74 liver-related deaths and 54 liver cancer deaths were identified (liver-related mortality rate of 4.0 per 10(5) person-years and liver cancer mortality rate of 2.9 per 10(5) person-years). Subjects with depressive symptoms had an increased risk of liver-related mortality with a corresponding multivariable aHR of 2.00 (95% CI 1.10-3.63) compared to those without depressive symptoms. This association was more evident in HBsAg-positive participants with a corresponding multivariable aHR of 4.22 (95% CI 1.81-9.88) than HBsAg-negative participants (P for interaction by HBsAg positivity=0.036). A similar pattern was observed in relation to liver cancer mortality. In this large cohort, depressive symptoms were associated with an increased risk of liver-related mortality, with a stronger association in HBsAg-positive individuals.

引用

页数：10