Emerging highly pathogenic H5 avian influenza viruses in France during winter 2015/16: phylogenetic analyses and markers for zoonotic potential

被引：42

作者：

Briand, F. ^{[1
,2
]}

Schmitz, A. ^{[1
,2
]}

Ogor, K. ^{[1
,2
]}

Le Prioux, A. ^{[1
,2
]}

Guillou-Cloarec, C. ^{[1
,2
]}

Guillemoto, C. ^{[1
,2
]}

Allee, C. ^{[1
,2
]}

Le Bras, M. ^{[1
,2
]}

Hirchaud, E. ^{[2
,3
]}

Quenault, H. ^{[2
,3
]}

Touzain, F. ^{[2
,3
]}

Cherbonnel-Pansart, M. ^{[1
,2
]}

Lemaitre, E. ^{[1
,2
]}

Courtillon, C. ^{[1
,2
]}

Gares, H. ^{[4
]}

Daniel, P. ^{[5
]}

Fediaevsky, A. ^{[6
]}

Massin, P. ^{[1
,2
]}

Blanchard, Y. ^{[2
,3
]}

Eterradossi, N. ^{[1
,2
]}

van der Werf, S. ^{[7
,8
]}

Jestin, V. ^{[8
]}

Niqueux, E. ^{[1
,2
]}

机构：

[1] Anses, Unite VIPAC LNR Influenza Aviaire, Ploufragan, France

[2] Univ Bretagne Loire, \, Rennes, France

[3] Anses, Unite Genet Virale & Biosecurite, Ploufragan, France

[4] Lab Dept Anal & Rech, Coulounieix Chamiers, France

[5] Lab Pyrenees Landes, Mt De Marsan, France

[6] Direct Gen Alimentat MAAF, Paris, France

[7] Inst Pasteur, Unite Genet Mol Virus ARN, CNR Grippe, Paris, France

[8] Anses, Grp Experts Specialise Sante Anim & Bien Etr Anim, Maisons Alfort, France

来源：

EUROSURVEILLANCE | 2017年 / 22卷 / 09期

关键词：

TRANSMISSION; IDENTIFICATION; INFECTION; RANGE;

D O I：

10.2807/1560-7917.ES.2017.22.9.30473

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Several new highly pathogenic (HP) H-5 avian influenza virus (AIV) have been detected in poultry farms from south-western France since November 2015, among which an HP H(5)N1. The zoonotic potential and origin of these AIVs immediately became matters of concern. One virus of each subtype H(5)N1 (150169a), H(5)N2 (150233) and H(5)N9 (150236) was characterised. All proved highly pathogenic for poultry as demonstrated molecularly by the presence of a polybasic cleavage site in their HA protein - with a sequence (HQRRKR/GLF) previously unknown among avian H-5 HPAI viruses - or experimentally by the in vivo demonstration of an intravenous pathogenicity index of 2.9 for the H(5)N1 HP isolate. Phylogenetic analyses based on the full genomes obtained by NGS confirmed that the eight viral segments of the three isolates were all part of avian Eurasian phylogenetic lineage but differed from the Gs/Gd/1/96-like lineage. The study of the genetic characteristics at specific amino acid positions relevant for modulating the adaptation to and the virulence for mammals showed that presently, these viruses possess most molecular features characteristic of AIV and lack some major characteristics required for efficient respiratory transmission to or between humans. The three isolates are therefore predicted to have no significant pandemic potential.

引用

页码：2 / 12

页数：11

共 36 条

[1]

ANSES, 2015, AV AG NAT SEC SAN AL

[2] The influenza virus resource at the national center for biotechnology information [J].

Bao, Yiming ;

Bolotov, Pavel ;

Dernovoy, Dmitry ;

Kiryutin, Boris ;

Zaslavsky, Leonid ;

Tatusova, Tatiana ;

Ostell, Jim ;

Lipman, David .

JOURNAL OF VIROLOGY, 2008, 82 (02) :596-601

[3] Avian Influenza A(H10N7) Virus-Associated Mass Deaths among Harbor Seals [J].

Bodewes, Rogier ;

Bestebroer, Theo M. ;

van der Vries, Erhard ;

Verhagen, Josanne H. ;

Herfst, Sander ;

Koopmans, Marion P. ;

Fouchier, Ron A. M. ;

Pfankuche, Vanessa M. ;

Wohlsein, Peter ;

Siebert, Ursula ;

Baumgaertner, Wolfgang ;

Osterhaus, Albert D. M. E. .

EMERGING INFECTIOUS DISEASES, 2015, 21 (04) :720-722

[4] Phylogeny and genotyping of recent avian low-pathogenic H5 subtype influenza viruses from French ducks [J].

Briand, F. -X. ;

Le Gall-Recule, G. ;

Guillou-Cloarec, C. ;

Ogor, K. ;

Jestin, V. .

JOURNAL OF GENERAL VIROLOGY, 2010, 91 :960-970

[5]

Centers for Disease Control and Prevention (CDC), 2012, H5NI GEN CHANG INV T

[6] Virologic findings in selected free-range mule duck farms at high risk for avian influenza infection [J].

Cherbonnel, M. ;

Lamande, J. ;

Allee, C. ;

Schmitz, A. ;

Ogor, K. ;

Le Gall-Recule, G. ;

Le Bras, M. O. ;

Guillemoto, C. ;

Pierre, I. ;

Picault, J. -P. ;

Jestin, V. .

AVIAN DISEASES, 2007, 51 (01) :408-413

[7] Animal health and welfare aspects of avian influenza and the risk of its introduction into the EU poultry holdings(1) Scientific Opinion of the Panel on Animal Health and Welfare [J].

European Food Safety Authority .

EFSA JOURNAL, 2008, 6 (06)

[8] Highly pathogenic avian influenza A subtype H5N8 [J].

European Food Safety Authority, European Centre for Disease Prevention and Control .

EFSA JOURNAL, 2014, 12 (12)

[9]

Food and Agriculture Organization of the United Nations (FAO), 2014, AV INFL H5N6 LAT ADD

[10] Design and Validation of a Microarray for Detection, Hemagglutinin Subtyping, and Pathotyping of Avian Influenza Viruses [J].

Gall, Astrid ;

Hoffmann, Bernd ;

Harder, Timm ;

Grund, Christian ;

Hoeper, Dirk ;

Beer, Martin .

JOURNAL OF CLINICAL MICROBIOLOGY, 2009, 47 (02) :327-334

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