Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease

被引:455
作者
Steven, Sebastian [1 ,2 ]
Frenis, Katie [1 ]
Oelze, Matthias [1 ]
Kalinovic, Sanela [1 ]
Kuntic, Marin [1 ]
Jimenez, Maria Teresa Bayo [1 ]
Vujacic-Mirski, Ksenija [1 ]
Helmstaedter, Johanna [1 ]
Kroeller-Schoen, Swenja [1 ]
Muenzel, Thomas [1 ,3 ]
Daiber, Andreas [1 ,3 ]
机构
[1] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Cardiol Lab Mol Cardiol 1, Ctr Cardiol, Mainz, Germany
[2] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Thrombosis & Hemostasis, Mainz, Germany
[3] German Ctr Cardiovasc Res DZHK, Partner Site Rhine Main, Mainz, Germany
关键词
ENDOTHELIUM-DEPENDENT VASODILATION; GLUCAGON-LIKE PEPTIDE-1; NITRIC-OXIDE SYNTHASE; SELECTIVE INHIBITOR IPRAGLIFLOZIN; ACUTE MYOCARDIAL-INFARCTION; CORONARY-ARTERY-DISEASE; INTIMA-MEDIA THICKNESS; KINASE-C ACTIVATION; SGLT2; INHIBITOR; ANGIOTENSIN-II;
D O I
10.1155/2019/7092151
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Cardiovascular disease is a leading cause of death and reduced quality of life, proven by the latest data of the Global Burden of Disease Study, and is only gaining in prevalence worldwide. Clinical trials have identified chronic inflammatory disorders as cardiovascular risks, and recent research has revealed a contribution by various inflammatory cells to vascular oxidative stress. Atherosclerosis and cardiovascular disease are closely associated with inflammation, probably due to the close interaction of inflammation with oxidative stress. Classical therapies for inflammatory disorders have demonstrated protective effects in various models of cardiovascular disease; especially established drugs with pleiotropic immunomodulatory properties have proven beneficial cardiovascular effects; normalization of oxidative stress seems to be a common feature of these therapies. The close link between inflammation and redox balance was also supported by reports on aggravated inflammatory phenotype in the absence of antioxidant defense proteins (e.g., superoxide dismutases, heme oxygenase-1, and glutathione peroxidases) or overexpression of reactive oxygen species producing enzymes (e.g., NADPH oxidases). The value of immunomodulation for the treatment of cardiovascular disease was recently supported by large-scale clinical trials demonstrating reduced cardiovascular mortality in patients with established atherosclerotic disease when treated by highly specific anti-inflammatory therapies (e.g., using monoclonal antibodies against cytokines). Modern antidiabetic cardiovascular drugs (e.g., SGLT2 inhibitors, DPP-4 inhibitors, and GLP-1 analogs) seem to share these immunomodulatory properties and display potent antioxidant effects, all of which may explain their successful lowering of cardiovascular risk.
引用
收藏
页数:26
相关论文
共 283 条
  • [31] Comorbidity and physical function: Results from the aging and longevity study in the Sirente geographic area (ilSIRENTE study)
    Cesari, M
    Onder, G
    Russo, A
    Zamboni, V
    Barillaro, C
    Ferrucci, L
    Pahor, M
    Bernabei, R
    Landi, F
    [J]. GERONTOLOGY, 2006, 52 (01) : 24 - 32
  • [32] Obligatory Role for B Cells in the Development of Angiotensin II-Dependent Hypertension
    Chan, Christopher T.
    Sobey, Christopher G.
    Lieu, Maggie
    Ferens, Dorota
    Kett, Michelle M.
    Diep, Henry
    Kim, Hyun Ah
    Krishnan, Shalini M.
    Lewis, Caitlin V.
    Salimova, Ekaterina
    Tipping, Peter
    Vinh, Antony
    Samuel, Chrishan S.
    Peter, Karlheinz
    Guzik, Tomasz J.
    Kyaw, Tin S.
    Toh, Ban-Hock
    Bobik, Alexander
    Drummond, Grant R.
    [J]. HYPERTENSION, 2015, 66 (05) : 1023 - 1033
  • [33] Cohen AJ, 2017, LANCET, V389, P1907, DOI [10.1016/S0140-6736(17)30505-6, 10.1016/s0140-6736(17)30505-6]
  • [34] Age-related macular degeneration
    Coleman, Hanna R.
    Chan, Chi-Chao
    Ferris, Frederick L., III
    Chew, Emily Y.
    [J]. LANCET, 2008, 372 (9652) : 1835 - 1845
  • [35] Correia LCL, 2016, NEW ENGL J MED, V375, P1798, DOI 10.1056/NEJMc1611289
  • [36] RAGE-induced Cytosolic ROS Promote Mitochondrial Superoxide Generation in Diabetes
    Coughlan, Melinda T.
    Thorburn, David R.
    Penfold, Sally A.
    Laskowski, Adrienne
    Harcourt, Brooke E.
    Sourris, Karly C.
    Tan, Adeline L. Y.
    Fukami, Kei
    Thallas-Bonke, Vicki
    Nawroth, Peter P.
    Brownlee, Michael
    Bierhaus, Angelika
    Cooper, Mark E.
    Forbes, Josephine M.
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2009, 20 (04): : 742 - 752
  • [37] Crespo MJ, 2003, CELL MOL BIOL, V49, P1311
  • [38] Microcirculation and oxidative stress
    Crimi, E.
    Ignarro, L. J.
    Napoli, C.
    [J]. FREE RADICAL RESEARCH, 2007, 41 (12) : 1364 - 1375
  • [39] IL-17 in Systemic Lupus Erythematosus
    Crispin, Jose C.
    Tsokos, George C.
    [J]. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2010,
  • [40] The aging kidney: role of endothelial oxidative stress and inflammation
    Csiszar, A.
    Toth, J.
    Peti-Peterdi, J.
    Ungvari, Z.
    [J]. ACTA PHYSIOLOGICA HUNGARICA, 2007, 94 (1-2) : 107 - 115