High frequency stimulation of the STN influences the activity of dopamine neurons in the rat

被引：66
作者：
Benazzouz, A
Gao, DM
Ni, ZG
Benabid, AL
机构：
[1] INSERM, U318, Lab Neurobiol Preclin, F-38043 Grenoble, France
[2] Jinzhou Med Coll, Dept Physiol, Jinzhou 121002, Liaoning, Peoples R China
来源：
NEUROREPORT | 2000年 / 11卷 / 07期
关键词：
basal ganglia; globus pallidus; high frequency stimulation; substantia nigra; subthalamic nucleus;
D O I：
10.1097/00001756-200005150-00043
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effect of high frequency stimulation (HFS) of the subthalamic nucleus (STN) on the spontaneous activity of substantia nigra pars compacta (SNc) dopaminergic neurons was investigated in normal rats and in rats with globus pallidus (GP) lesions. In normal rats, the spontaneous activity of SNc neurons did not significantly differ from that of rats with GP lesions (4.2 +/- 2.2 versus 4.4 +/- 2.6 spikes/s). STN-HFS induced an increase of firing rate in the majority of tested cells in normal (76%) and GP-lesioned rats (73%) with an after-effect of 34.4+/-3.4 and 33.2+/-3.1 s, respectively. These results demonstrate that STN-HFS influences the activity of the SNc dopaminergic neurons by increasing their firing rate and that this increase of activity is independent of the globus pallidus. NeuroReport 11:1593-1596 (C) 2000 Lippincott Williams & Wilkins.
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页码：1593 / 1596
页数：4
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