Antiproliferative constituents from Umbelliferae plants.: IX.: New triterpenoid glycosides from the fruits of Bupleurum rotundifolium

被引：10

作者：

Fujioka, Toshihiro ^{[1
]}

Yoshida, Keisuke ^{[1
]}

Shibao, Hiroko ^{[1
]}

Nagao, Tsuneatsu ^{[1
]}

Yoshida, Miyako ^{[1
]}

Matsunaga, Kazuhisa ^{[1
]}

Takata, Jiro ^{[1
]}

Karube, Yoshiharu ^{[1
]}

Iwase, Yukiko ^{[1
]}

Okabe, Hikaru ^{[1
]}

Mihashi, Kunihide ^{[1
]}

机构：

[1] Fukuoka Univ, Fac Pharmaceut Sci, Jonan Ku, Fukuoka 8140180, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2006年 / 54卷 / 12期

关键词：

antiproliferative constituent; Bupleurum rotundifolium; Umbelliferae; 13; beta; 28-epoxy oleanane-type triterpene glycoside;

D O I：

10.1248/cpb.54.1694

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The MeOH extract of the fruits of Bupleurum rotundifolium showed inhibitory activity against human gastric adenocarcinoma (MK-1) cell growth. Bioactivity-guided fractionation of the MeOH extract led to the isolation of four new triglycosides of 13 beta,28-epoxy oleanane-type triterpenes, named rotundiosides 0, Q, S and T; 12 new glycosides of oleanane-type triterpenes, named rotundiosides J-N, P, R, U-Y, and others; echinocystic acid 3-O-sulfate; and three known oleanane-type triterpene glycosides, rotundiosides A, F and G. The structures of the new isolates were determined based on chemical and spectroscopic evidence. The GI(50), of isolates against MK-1, HeLa and B16F10 cell lines are reported.

引用

页码：1694 / 1704

页数：11

共 5 条

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Fujioka, T
Yoshida, K
Fujii, H
Nagao, T
Okabe, H
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CHEMICAL & PHARMACEUTICAL BULLETIN, 2003, 51 (04) : 365 - 372
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Ikeda, R
Nagao, T
Okabe, H
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Matsunaga, H
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CHEMICAL & PHARMACEUTICAL BULLETIN, 1998, 46 (05) : 875 - 878
[3] Antiproliferative constituents from Umbelliferae plants.: V.: A new furanocoumarin and falcarindiol furanocoumarin ethers from the root of Angelica japonica
Fujioka, T
Furumi, K
Fujii, H
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CHEMICAL & PHARMACEUTICAL BULLETIN, 1999, 47 (01) : 96 - 100
[4] Antiproliferative constituents in Umbelliferae plants - II. Screening for polyacetylenes in some Umbelliferae plants, and isolation of panaxynol and falcarindiol from the root of Heracleum moellendorffii
Nakano, Y
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Okabe, H
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 1998, 21 (03) : 257 - 261
[5] Antiproliferative constituents from Umbelliferae plants VII.: Active triterpenes and rosmarinic acid from Centella asiatica
Yoshida, M
Fuchigami, M
Nagao, T
Okabe, H
Matsunaga, K
Takata, J
Karube, Y
Tsuchihashi, R
Kinjo, J
Mihashi, K
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BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2005, 28 (01) : 173 - 175

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