Successful therapeutic use of a single-dose of rituximab on relapse in adults with minimal change nephrotic syndrome

被引：0
|
作者：
Sawara, Y. [1 ]
Itabashi, M. [1 ]
Kojima, C. [1 ]
Tabata, H. [1 ]
Kamei, D. [1 ]
Kawanishi, K. [1 ]
Moriyama, T. [1 ]
Sugiura, H. [1 ]
Tsukada, M. [1 ]
Takei, T. [1 ]
Ogawa, T. [1 ]
Yoshida, T. [1 ]
Arai, J. [1 ]
Uchida, K. [1 ]
Tsuchiya, K. [1 ]
Nitta, K. [1 ]
机构：
[1] Tokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, Japan
来源：
CLINICAL NEPHROLOGY | 2009年 / 72卷 / 01期
关键词：
minimal change nephritic syndrome; relapse; rituximab; remission; ANTI-CD20;
D O I：
暂无
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Minimal change nephrotic syndrome (MCNS) usually is considered to have a good renal prognosis, but the frequency of relapses is a therapeutic challenge to physicians. The treatment of patients with multiple relapses remains a matter of controversy, because few controlled studies are available. We report the case of a 25-year-old man who experienced relapses of MCNS. Single-dose rituximab therapy (total dose 500 mg) was given during the fourth relapse. Complete remission occurred 10 days later, when no CD19/20-positive B cells were detected in the blood. This the first report of efficacy of single-dose rituximab therapy to treat multi-relapsing MCNS in an adult patient.
引用
收藏
页码：69 / 72
页数：4
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