Successful therapeutic use of a single-dose of rituximab on relapse in adults with minimal change nephrotic syndrome

被引：0

作者：

Sawara, Y. ^{[1
]}

Itabashi, M. ^{[1
]}

Kojima, C. ^{[1
]}

Tabata, H. ^{[1
]}

Kamei, D. ^{[1
]}

Kawanishi, K. ^{[1
]}

Moriyama, T. ^{[1
]}

Sugiura, H. ^{[1
]}

Tsukada, M. ^{[1
]}

Takei, T. ^{[1
]}

Ogawa, T. ^{[1
]}

Yoshida, T. ^{[1
]}

Arai, J. ^{[1
]}

Uchida, K. ^{[1
]}

Tsuchiya, K. ^{[1
]}

Nitta, K. ^{[1
]}

机构：

[1] Tokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, Japan

来源：

CLINICAL NEPHROLOGY | 2009年 / 72卷 / 01期

关键词：

minimal change nephritic syndrome; relapse; rituximab; remission; ANTI-CD20;

D O I：

暂无

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Minimal change nephrotic syndrome (MCNS) usually is considered to have a good renal prognosis, but the frequency of relapses is a therapeutic challenge to physicians. The treatment of patients with multiple relapses remains a matter of controversy, because few controlled studies are available. We report the case of a 25-year-old man who experienced relapses of MCNS. Single-dose rituximab therapy (total dose 500 mg) was given during the fourth relapse. Complete remission occurred 10 days later, when no CD19/20-positive B cells were detected in the blood. This the first report of efficacy of single-dose rituximab therapy to treat multi-relapsing MCNS in an adult patient.

引用

页码：69 / 72

页数：4

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