The Emerging Role of the RAB25 Small GTPase in Cancer

被引：63

作者：

Agarwal, Roshan ^{[1
,2
]}

Jurisica, Igor ^{[3
]}

Mills, Gordon B. ^{[1
]}

Cheng, Kwai Wa ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, Unit 950, Houston, TX 77030 USA

[2] Univ London Imperial Coll Sci Technol & Med, Dept Med Oncol, London, England

[3] Ontario Canc Inst, Div Signaling Biol, Toronto, ON M4X 1K9, Canada

来源：

TRAFFIC | 2009年 / 10卷 / 11期

关键词：

breast; cancer; CATX-8; endocytosis; ovarian; Rab25; small GTPases; TRANSFERASE INHIBITOR R115777; CANINE KIDNEY-CELLS; SIGNAL-TRANSDUCTION; BREAST-CANCER; IN-VIVO; ALPHA-5-BETA-1; INTEGRIN; 3D MICROENVIRONMENTS; BINDING-PROTEIN; EXPRESSION; GROWTH;

D O I：

10.1111/j.1600-0854.2009.00969.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

RAB25, a member of the rat sarcoma (RAS) family of small GTPase, has been implicated in the pathophysiology of ovarian, breast and other cancers. Its role in endosomal transport and recycling of cell-surface receptors and signaling proteins presents a novel paradigm for the disruption of cellular pathways and promotion of tumor development and aggressiveness. Variations in structure and post-translational modifications control the localization of RAS superfamily proteins to specific subcellular compartments and recruitment of downstream effectors, allowing these small GTPases to function as sophisticated modulators of a complex and diverse range of cellular processes. Here, we review the link between RAB25 and tumor development and current knowledge regarding its possible roles in cancer.

引用

页码：1561 / 1568

页数：8

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