Pharmacogenetic prediction of clozapine response

被引：233

作者：

Arranz, MJ

Munro, J

Birkett, J

Bolonna, A

Mancama, D

Sodhi, M

Lesch, KP

Meyer, JFW

Sham, P

Collier, DA

Murray, RM

Kerwin, RW

机构：

[1] Inst Psychiat, Dept Clin Neurophysiol, London SE5 8AF, England

[2] Inst Psychiat, Dept Psychol Med, London SE5 8AF, England

[3] Univ Wurzburg, Dept Psychiat, D-97080 Wurzburg, Germany

来源：

LANCET | 2000年 / 355卷 / 9215期

关键词：

D O I：

10.1016/S0140-6736(00)02221-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We did association studies in multiple candidate genes to find the combination of polymorphisms that give the best predictive value of response to clozapine In schizophrenic patients. A combination of six polymorphisms in neurotransmitter-receptor-related genes resulted in 76.7% success in the prediction of clozapine response (p=0.0001) and a sensitivity of 95% (+/-0.04) for satisfactory response. These results will form the basis for a simple test to enhance the usefulness of clozapine in psychiatric treatment.

引用

页码：1615 / 1616

页数：2

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