BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders

被引：735

作者：

Mattson, MP ^{[1
]}

Maudsley, S

Martin, B

机构：

[1] NIA, Intramural Res Program, Neurosci Lab, Baltimore, MD 21224 USA

[2] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

来源：

TRENDS IN NEUROSCIENCES | 2004年 / 27卷 / 10期

关键词：

D O I：

10.1016/j.tins.2004.08.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain-derived neurotrophic factor (BDNF) and serotonin (5-hydroxytryptamine, 5-HT) are known to regulate synaptic plasticity, neurogenesis and neuronal survival in the adult brain. These two signals co-regulate one another such that 5-HT stimulates the expression of BDNF, and BDNF enhances the growth and survival of 5-HT neurons. Impaired 5-HT and BDNF signaling is central to depression and anxiety disorders, but could also play important roles in the pathogenesis of several age-related disorders, including insulin resistance syndrome, Alzheimer's disease and Huntington's disease. Enhancement of BDNF signaling may be a key mechanism whereby cognitive stimulation, exercise, dietary restriction and antidepressant drugs preserve brain function during aging. Behavioral and pharmacological manipulations that enhance 5-HT and BDNF signaling could help promote healthy brain aging.

引用

页码：589 / 594

页数：6

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