Catalytic Enantioselective Synthesis of α,β-Diamino Acid Derivatives

被引：100

作者：

Li, Le ^{[1
]}

Ganesh, Madhu ^{[1
]}

Seidel, Daniel ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 33期

关键词：

DIRECT MANNICH REACTION; ASYMMETRIC-SYNTHESIS; CONJUGATE ADDITION; GLYCINE DERIVATIVES; HENRY REACTION; AMINO-ACID; IMINES; ORGANOCATALYSIS; MALONATE; ESTERS;

D O I：

10.1021/ja9034494

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Highly enantio- and diastereoselective organocatalytic Mannich additions of alpha-isothiocyanato imides to sulfonyl imines are reported. Enantiomerically enriched syn-alpha,beta-diamino acid derivatives can be obtained in excellent yields using catalyst loadings as low as 0.25 mol %.

引用

页码：11648 / +

页数：3

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