Sex differences in renal mitochondrial function: a hormone-gous opportunity for research

被引：34

作者：

Sultanova, Regina F. ^{[1
,2
]}

Schibalski, Ryan ^{[1
]}

Yankelevich, Irina A. ^{[2
,3
]}

Stadler, Krisztian ^{[4
]}

Ilatovskaya, Daria, V ^{[1
]}

机构：

[1] Med Univ South Carolina, Dept Med, Div Nephrol, Charleston, SC 29425 USA

[2] St Petersburg State Chem Pharmaceut Univ, St Petersburg, Russia

[3] Insitute Expt Med, St Petersburg, Russia

[4] Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY | 2020年 / 319卷 / 06期

基金：

美国国家卫生研究院;

关键词：

female; kidney; male; mitochondria; sex differences; GENDER-DIFFERENCES; ORNITHINE AMINOTRANSFERASE; INDUCED NEPHROTOXICITY; ANDROGEN-RECEPTOR; OXIDATIVE STRESS; SKELETAL-MUSCLE; KIDNEY; ESTROGEN; TESTOSTERONE; EXPRESSION;

D O I：

10.1152/ajprenal.00320.2020

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Sex differences (biological distinctions between males and females) present a complex interplay of genetic, developmental, biological, and environmental factors. More and more studies are shedding light on the importance of sex differences in normal physiology and susceptibility to cancer, cardiovascular and renal conditions, and neurodegenerative diseases. This mini-review is devoted to the role of sex dimorphisms in renal function, with a focus on the distinctions between male and female mitochondria. Here, we cover the aspects of renal mitochondrial bioenergetics where sex differences have been reported to date, for instance, biogenesis, reactive oxygen species production, and oxidative stress. Special attention is devoted to the effects of sex hormones, such as estrogen and testosterone, on mitochondrial bioenergetics in the kidney in physiology and pathophysiology.

引用

页码：F1117 / F1124

页数：8

共 122 条

[1] Identification and characterization of a functional mitochondrial angiotensin system [J].