Synthesis and antimicrobial activity of new bromine-rich pyrrole derivatives related to monodeoxypyoluteorin

被引：76

作者：

Raimondi, Maria Valeria ^{[1
]}

Cascioferro, Stella ^{[1
]}

Schillaci, Domenico ^{[1
]}

Petruso, Salvatore ^{[1
]}

机构：

[1] Univ Palermo, Dipartimento Chim & Tecnol Farmaceut, I-90123 Palermo, Italy

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2006年 / 41卷 / 12期

关键词：

antimicrobics; bromopyrroles; pyoluteorin analogs;

D O I：

10.1016/j.ejmech.2006.07.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and antimicrobial activity of new pyrrole derivatives structurally related to monodeoxypyoluteorin are described. The insertion of a keto or methylene spacer between the phenol group and the pyrroloyl moiety of brominated 2-(2'-hydroxybenzoyl)pyrroles leads to a decrease of the antibacterial activity. (c) 2006 Elsevier Masson SAS. All rights reserved.

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页码：1439 / 1445

页数：7

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