Daily consumption of pro-vitamin A biofortified (yellow) cassava improves serum retinol concentrations in preschool children in Nigeria: a randomized controlled trial

被引:18
作者
Afolami, Ibukun [1 ,2 ]
Mwangi, Martin N. [1 ,3 ]
Samuel, Folake [2 ]
Boy, Erick [4 ]
Ilona, Paul [5 ]
Talsma, Elise F. [1 ]
Feskens, Edith [1 ]
Melse-Boonstra, Alida [1 ]
机构
[1] Wageningen Univ & Res, Div Human Nutr & Hlth, Wageningen, Netherlands
[2] Univ Ibadan, Dept Human Nutr & Dietet, Ibadan, Nigeria
[3] Univ Malawi, Coll Med, Training & Res Unit Excellence, Blantyre, Malawi
[4] HarvestPlus, Washington, DC USA
[5] HarvestPlus, Ibadan, Nigeria
关键词
vitamin A; biofortification; cassava; preschool children; Nigeria; SOLUBLE TRANSFERRIN RECEPTOR; STABLE-ISOTOPE-DILUTION; C-REACTIVE PROTEIN; A STATUS; BETA-CAROTENE; BINDING-PROTEIN; HEMOGLOBIN CONCENTRATIONS; PLANT FOODS; INFLAMMATION; MALARIA;
D O I
10.1093/ajcn/nqaa290
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Vitamin A deficiency is a public health problem in sub-Saharan Africa. Pro-vitamin A biofortified (yellow) cassava has the potential to contribute significantly to improve vitamin A status, especially in populations that are difficult to reach with other strategies. Objectives: The study aimed at determining the efficacy of biofortified cassava to improve vitamin A status of Nigerian preschool children. Methods: An open-label randomized controlled trial was conducted in southwestern Nigeria. In total, 176 preschool children (aged 3-5 y) were randomized into 2 parallel arms comprising an experimental group (n = 88), fed foods prepared from biofortified (yellow) cassava, and a control group (n = 88), fed foods prepared from white cassava, twice a day, 6 d a week for 93 d. Results: A total of 159 children completed the trial (yellow cassava group, n = 80; white cassava group, n = 79). Children consumed 221 and 74 mu g/d retinol activity equivalents from intervention foods in the yellow and white cassava groups, respectively. The treatment effect on serum retinol concentrations at the end of the feeding trial was 0.06 mu mol/L (95% CI: 0.004, 0.124 mu mol/L), after adjustment for baseline retinol concentrations, inflammation, and asymptomatic malaria status. No significant treatment effects were detected for serum beta-carotene (adjusted effect: 3.9%; 95% CI:-0.6%, 8.6%) and gut permeability (adjusted effect: 0.002; 95% CI: -0.089, 0.092), but a significant effect was detected for hemoglobin concentrations (adjusted effect: 3.08 g/L; 95% CI: 0.38, 5.78 g/L). Conclusions: Daily consumption of beta-carotene from biofortified cassava improved serum retinol and hemoglobin concentrations modestly in Nigerian preschool children.
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收藏
页码:221 / 231
页数:11
相关论文
共 55 条
[11]   Comparison of the World Health Organization (WHO) Child Growth Standards and the National Center for Health Statistics/WHO international growth reference: implications for child health programmes [J].
de Onis, Mercedes ;
Onyango, Adelheid W. ;
Borghi, Elaine ;
Garza, Cutberto ;
Yang, Hong .
PUBLIC HEALTH NUTRITION, 2006, 9 (07) :942-947
[12]   Orange fruit is more effective than are dark-green, leafy vegetables in increasing serum concentrations of retinol and β-carotene in schoolchildren in Indonesia [J].
de Pee, S ;
West, CE ;
Permaesih, D ;
Martuti ;
Muhilal ;
Hautvast, JGAJ .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1998, 68 (05) :1058-1067
[13]   Bias, precision and statistical power of analysis of covariance in the analysis of randomized trials with baseline imbalance: a simulation study [J].
Egbewale, Bolaji E. ;
Lewis, Martyn ;
Sim, Julius .
BMC MEDICAL RESEARCH METHODOLOGY, 2014, 14
[14]   Combined measurement of ferritin, soluble transferrin receptor, retinol binding protein, and C-reactive protein by an inexpensive, sensitive, and simple sandwich enzyme-linked immunosorbent assay technique [J].
Erhardt, JG ;
Estes, JE ;
Pfeiffer, CM ;
Biesalski, HK ;
Craft, NE .
JOURNAL OF NUTRITION, 2004, 134 (11) :3127-3132
[15]  
Federal Government of Nigeria, 2006, NIG POP COMM
[16]  
Food and Agriculture Organization (FAO), 2017, FOOD OUTL BIANN REP, VVolume November
[17]   Analysis of covariance with pre-treatment measurements in randomized trials: Comparison of equal and unequal slopes [J].
Funatogawa, Ikuko ;
Funatogawa, Takashi .
BIOMETRICAL JOURNAL, 2011, 53 (05) :810-821
[18]   Biofortified orange maize is as efficacious as a vitamin A supplement in Zambian children even in the presence of high liver reserves of vitamin A: a community-based, randomized placebo-controlled trial [J].
Gannon, Bryan ;
Kaliwile, Chisela ;
Arscott, Sara A. ;
Schmaelzle, Samantha ;
Chileshe, Justin ;
Kalungwana, Ngandwe ;
Mosonda, Mofu ;
Pixley, Kevin ;
Masi, Cassim ;
Tanumihardjo, Sherry A. .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2014, 100 (06) :1541-1550
[19]  
Gibson R.S., 2008, An Interactive 24-Hour Recall for Assessing the Adequacy of Iron and Zinc Intakes in Developing Countries
[20]   Plasma Retinol Kinetics and β-Carotene Bioefficacy Are Quantified by Model-Based Compartmental Analysis in Healthy Young Adults with Low Vitamin A Stores [J].
Green, Michael H. ;
Ford, Jennifer Lynn ;
Oxley, Anthony ;
Green, Joanne Balmer ;
Park, Hyunjin ;
Berry, Philip ;
Boddy, Alan V. ;
Lietz, Georg .
JOURNAL OF NUTRITION, 2016, 146 (10) :2129-2136