Integrated bioinformatics analysis of miRNA expression in osteosarcoma

被引：29

作者：

Wang, Maoyuan ^{[1
]}

Xie, Ruilian ^{[2
]}

Si, Haibo ^{[3
]}

Shen, Bin ^{[3
]}

机构：

[1] Sichuan Univ, West China Sch Med, Chengdu, Peoples R China

[2] Gannan Med Coll, Dept Med Oncol, Affiliated Hosp 1, Ganzhou, Peoples R China

[3] Sichuan Univ, West China Hosp, Dept Orthopaed, 37 Guoxue Rd, Chengdu 610041, Peoples R China

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2017年 / 45卷 / 05期

关键词：

miRNA expression; osteosarcoma; SIX3; target genes; CHOLINE PHOSPHOLIPID-METABOLISM; GROWTH-FACTOR RECEPTOR; CELL-PROLIFERATION; GENE; CANCER; TRANSACTIVATION; TRANSCRIPTION; COREPRESSOR; PROGRESSION; SIGNATURES;

D O I：

10.1080/21691401.2016.1196456

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The expression of miRNA influencing the pathogenesis of OS have been reported previously, however, different samples selection and sequencing platforms made obvious differences in miRNA expression analysis. We aim to identify reliable prognostic and treatment biomarkers for OS by systematic analysis of miRNAs expression data sets from biased data set. Seven miRNA data sets were selected from corresponding articles. Collectively, two miRNAs, hsa-miR-19-3p and hsa-miR106b-3p, and transcription factor SIX3 were identified and may be reliable markers for prognostic and treatment of osteosarcoma.

引用

页码：936 / 943

页数：8

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