Comparison of Endothelial Barrier Functional Recovery After Implantation of a Novel Biodegradable-Polymer Sirolimus-Eluting Stent in Comparison to Durable- and Biodegradable-Polymer Everolimus-Eluting Stents

被引：11

作者：

Sakamoto, Atsushi ^{[1
]}

Torii, Sho ^{[1
]}

Jinnouchi, Hiroyuki ^{[1
]}

Guo, Liang ^{[1
]}

Cornelissen, Anne ^{[1
]}

Kuntz, Salome ^{[1
]}

Cheng, Qi ^{[1
]}

Fernandez, Raquel ^{[1
]}

Paek, Ka Hyun ^{[1
]}

Harris, Kathryn ^{[2
]}

Srivastava, Mukta C. ^{[2
]}

Kolodgie, Frank D. ^{[1
]}

Virmani, Renu ^{[1
]}

Finn, Aloke, V ^{[1
,2
]}

机构：

[1] CVPath Inst Inc, 19 Firstfield Rd, Gaithersburg, MD 20878 USA

[2] Univ Maryland, Sch Med, Baltimore, MD 21201 USA

来源：

CARDIOVASCULAR REVASCULARIZATION MEDICINE | 2021年 / 24卷

关键词：

Drug eluting stent; Biodegradable polymer; Durable polymer; Endothelial function; Vascular permeability;

D O I：

10.1016/j.carrev.2020.08.012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims: The advantage of biodegradable-polymer drug-eluting stents (BP-DES) versus durable-polymer (DP) DES remains uncertain. We compared neointimal formation and endothelial barrier function of new BP sirolimus-eluting stents (BP-SES, BuMA Supreme (R)) to other contemporary BP-DES, DP-DES, and bare metal stents (BMS). Methods and results: Light microscopic assessment in swine coronary arteries showed comparable neointimal formation between BP-SES and DP everolimus-eluting stent (DP-EES). The performance of BP-SES was compared with DP-EES (Xience Xpedition (R)), BP-EES (Synergy (R)), and BMS (Multi-Link Vision (R)) at 45- and 90-days in rabbit ilio-femoral arteries using Evans blue dye (EBD) followed by immunostaining for endothelial barrier proteins (p120/vascular endothelial-cadherin [VE-cad]) to evaluate endothelial barrier function and scanning electron microscopy (SEM) to determine strut tissue coverage. BMS followed by BP-SES and BP-EES exhibited smaller EBD positive areas versus that of DP-EES at 45- and 90-days. p120/VE-cad immunostaining and SEM-determined strut coverage was greater at 45- and 90-days for BMS followed by all DESs. Regardless of stent type, the lack of p120/VE-cad co-localization showed greater leukocyte and platelet aggregation. Conclusion: Three types of DES showed different endothelial healing pattern regardless their equivalent suppression of neointimal formation. (C) 2020 Elsevier Inc. All rights reserved.

引用

页码：1 / 10

页数：10

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