Immune senescence and brain aging: can rejuvenation of immunity reverse memory loss?

被引：40
作者：
Ron-Harel, Noga [1 ]
Schwartz, Michal [1 ]
机构：
[1] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel
来源：
TRENDS IN NEUROSCIENCES | 2009年 / 32卷 / 07期
基金：
欧洲研究理事会;
关键词：
REGULATORY T-CELLS; MILD COGNITIVE IMPAIRMENT; MESSENGER-RNA EXPRESSION; MOUSE DENTATE GYRUS; SPINAL-CORD-INJURY; ALZHEIMERS-DISEASE; PROTECTIVE AUTOIMMUNITY; MULTIPLE-SCLEROSIS; HIPPOCAMPAL NEUROGENESIS; IFN-GAMMA;
D O I：
10.1016/j.tins.2009.03.003
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The factors that determine brain aging remain a mystery. Do brain aging and memory loss reflect processes occurring only within the brain? Here, we present a novel view, linking aging of adaptive immunity to brain senescence and specifically to spatial memory deterioration. Inborn immune deficiency, in addition to sudden imposition of immune malfunction in young animals, results in cognitive impairment. As a corollary, immune restoration at adulthood or in the elderly results in a reversal of memory loss. These results, together with the known deterioration of adaptive immunity in the elderly, suggest that memory loss does not solely reflect chronological age; rather, it is an outcome of the gap between an increasing demand for maintenance (age-related risk-factor accumulation) and the reduced ability of the immune system to meet these needs.
引用
收藏
页码：367 / 375
页数：9
相关论文
共 130 条
  • [1] Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease
    Adlard, PA
    Perreau, VM
    Pop, V
    Cotman, CW
    [J]. JOURNAL OF NEUROSCIENCE, 2005, 25 (17) : 4217 - 4221
  • [2] Adler Ubiratan C., 2008, Inflammation & Allergy Drug Targets, V7, P19, DOI 10.2174/187152808784165216
  • [3] Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
    Ajami, Bahareh
    Bennett, Jami L.
    Krieger, Charles
    Tetzlaff, Wolfram
    Rossi, Fabio M. V.
    [J]. NATURE NEUROSCIENCE, 2007, 10 (12) : 1538 - 1543
  • [4] Potential therapeutic effects of exercise to the brain
    Ang, E. T.
    Gomez-Pinilla, F.
    [J]. CURRENT MEDICINAL CHEMISTRY, 2007, 14 (24) : 2564 - 2571
  • [5] Adaptive Immune Neuroprotection in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice
    Banerjee, Rebecca
    Mosley, R. Lee
    Reynolds, Ashley D.
    Dhar, Alok
    Jackson-Lewis, Vernice
    Gordon, Paul H.
    Przedborski, Serge
    Gendelman, Howard E.
    [J]. PLOS ONE, 2008, 3 (07):
  • [6] Proteolysis of proBDNF Is a Key Regulator in the Formation of Memory
    Barnes, Philip
    Thomas, Kerrie L.
    [J]. PLOS ONE, 2008, 3 (09):
  • [7] IFN-γ enhances neurogenesis in wild-type mice and in a mouse model of Alzheimer's disease
    Baron, Rona
    Nemirovsky, Anna
    Harpaz, Idan
    Cohen, Hagit
    Owens, Trevor
    Monsonego, Alon
    [J]. FASEB JOURNAL, 2008, 22 (08) : 2843 - 2852
  • [8] Insulin/IGF signalling in neurogenesis
    Bateman, J. M.
    McNeill, H.
    [J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 2006, 63 (15) : 1701 - 1705
  • [9] CD4+T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS
    Beers, David R.
    Henkel, Jenny S.
    Zhao, Weihua
    Wang, Jinghong
    Appel, Stanley H.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (40) : 15558 - 15563
  • [10] Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease
    Benner, EJ
    Mosley, RL
    Destache, CJ
    Lewis, TB
    Jackson-Lewis, V
    Gorantla, S
    Nemachek, C
    Green, SR
    Przedborski, S
    Gendelman, HE
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (25) : 9435 - 9440
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