Urban-rural differences in breast cancer incidence by hormone receptor status across 6 years in Egypt

被引:47
作者
Dey, Subhojit [1 ]
Soliman, Amr S. [1 ]
Hablas, Ahmad [2 ]
Seifeldin, Ibrahim A. [3 ]
Ismail, Kadry [2 ]
Ramadan, Mohamed [3 ]
El-Hamzawy, Hesham [3 ]
Wilson, Mark L. [1 ]
Banerjee, Mousumi [4 ]
Boffetta, Paolo [5 ]
Harford, Joe [6 ]
Merajver, Sofia D. [7 ]
机构
[1] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
[2] Gharbiah Canc Soc, Tanta, Gharbiah, Egypt
[3] Tanta Canc Ctr, Tanta, Gharbiah, Egypt
[4] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA
[5] Int Agcy Res Canc, F-69372 Lyon, France
[6] NCI, Off Int Affairs, Bethesda, MD 20892 USA
[7] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA
关键词
Breast cancer incidence; Hormone receptor status; Mammary stem cells; Xenoestrogens; Egypt; PERSISTENT ORGANIC POLLUTANTS; ESTROGEN-RECEPTOR; RISK-FACTORS; ENVIRONMENTAL-POLLUTANTS; BISPHENOL-A; STEM-CELLS; EPIDEMIOLOGY; TUMOR; IDENTIFICATION; POPULATION;
D O I
10.1007/s10549-009-0427-9
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Breast cancer incidence is higher in developed countries with higher rates of estrogen receptor positive (ER+) tumors. ER+ tumors are caused by estrogenic exposures although known exposures explain approximately 50% of breast cancer risk. Unknown risk factors causing high breast cancer incidence exist that are estrogenic and development-related. Xenoestrogens are such risk factors but are difficult to study since developed countries lack unexposed populations. Developing countries have urban-rural populations with differential exposure to xenoestrogens. This study assessed urban-rural breast cancer incidence classified by hormone receptor status using data from Gharbiah population-based cancer registry in Egypt from 2001 to 2006. Urban ER+ incidence rate (per 100,000 women) was 2-4 times (IRR = 3.36, 95% CI = 4.84, 2.34) higher than rural incidence rate. ER-incidence rate was 2-3 times (IRR = 1.86, 95% CI = 2.38, 1.45) higher in urban areas than in rural areas. Our findings indicate that urban women may probably have a higher exposure to xenoestrogens.
引用
收藏
页码:149 / 160
页数:12
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