The effects of a new antidiabetic glycinium [(pyridine-2, 6-dicarboxylato) oxovanadate (V)] complex in high-fat diet of streptozotocin-induced diabetic rats

被引：2

作者：

Komeili, Gholamreza ^{[1
]}

Ghasemi, Fatemeh ^{[2
]}

Rezvani, Ali Reza ^{[2
]}

Ghasemi, Khaled ^{[2
]}

Sameni, Farzaneh Khadem ^{[3
]}

Hashemi, Mohammad ^{[4
,5
]}

机构：

[1] Zahedan Univ Med Sci, Sch Med, Dept Physiol, Zahedan, Iran

[2] Univ Sistan & Baluchestan, Fac Sci, Dept Chem, Zahedan 98155987, Iran

[3] Islamic Azad Univ, Fac Med, Zahedan, Iran

[4] Zahedan Univ Med Sci, Genet Noncommunicable Dis Res Ctr, Zahedan, Iran

[5] Zahedan Univ Med Sci, Sch Med, Dept Clin Biochem, Zahedan, Iran

来源：

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY | 2022年 / 128卷 / 01期

关键词：

Diabetes mellitus; metformin; glycinium [(pyridine-2; 6-dicarboxylato) oxovanadate (V); ORAL VANADYL SULFATE; ANTIOXIDANT STATUS; GLUCOSE; METFORMIN; PREVALENCE; LIVER; CHEMISTRY; RESTORES; MELLITUS;

D O I：

10.1080/13813455.2019.1663218

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Objective: The present study aimed to evaluate the antidiabetic effects of glycinium [(pyridine-2, 6-dicarboxylato) oxovanadate (V)] complex in type 2 diabetes rat model. Materials and methods: Rats were allocated into 6 groups. Group I, nondiabetic rats; Group II, diabetic rats; Group III, diabetic rats receiving an intraperitoneal (i.p.) injection of metformin (45 mg/kg); Groups IV, V and VI were diabetic rats receiving i.p. injection of 5, 10, and 20 mg/kg of the complex for 3 weeks, respectively. Fasting blood glucose (FBG), insulin, liver enzymes, malondialdehyde (MDA), total antioxidant capacity (TAC), lipid profile, and HbA1c were measured. Results: AST, ALT and GGT activities and MDA levels were increased, while TAC was decreased in diabetic animals. Treatment of diabetic rats improved the HOMA-IR and returned HbA1c level to the normal value as well as elevated TAC and reduced MDA level. Conclusion: We found that the complex possesses antidiabetic properties in experimental diabetes.

引用

页码：80 / 86

页数：7

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