Nickel-Catalyzed Difunctionalization of Unactivated Alkenes Initiated by Unstabilized Enolates

被引：31
作者：
Huang, David [1 ]
Olivieri, Diego [1 ]
Sun, Yang [1 ]
Zhang, Pengpeng [1 ]
Newhouse, Timothy R. [1 ]
机构：
[1] Yale Univ, Dept Chem, 225 Prospect St, New Haven, CT 06520 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2019年 / 141卷 / 41期
基金：
瑞士国家科学基金会;
关键词：
INTRAMOLECULAR HYDROALKYLATION; COUPLING REACTIONS; REDUCTIVE DICARBOFUNCTIONALIZATION; ALKYL BROMIDES; OLEFINS; METAL; ZINC; EFFICIENT; CYCLIZATION; REAGENTS;
D O I：
10.1021/jacs.9b09245
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This report demonstrates the possibility of a nickel-catalyzed difunctionalization of unactivated alkenes initiated by an unstabilized enolate nucleophile. The process tolerates a diverse range of electrophiles, including aryl, heteroaryl, alkenyl, and amino electrophiles. An electron-deficient phosphine ligand and a tetrabutylammonium salt additive were crucial for promoting efficient vicinal difunctionalization.
引用
收藏
页码：16249 / 16254
页数：6
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