Measuring proliferation in breast cancer: practicalities and applications

被引：145
作者：
Beresford, Mark J. [1 ]
Wilson, George D.
Makris, Andreas
机构：
[1] Mt Vernon Canc Ctr, Northwood, Middx, England
[2] William Beaumont Hosp, Dept Radiat Oncol, Royal Oak, MI USA
来源：
BREAST CANCER RESEARCH | 2006年 / 8卷 / 06期
关键词：
D O I：
10.1186/bcr1618
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Various methods are available for the measurement of proliferation rates in tumours, including mitotic counts, estimation of the fraction of cells in S-phase of the cell cycle and immunohistochemistry of proliferation-associated antigens. The evidence, advantages and disadvantages for each of these methods along with other novel approaches is reviewed in relation to breast cancer. The potential clinical applications of proliferative indices are discussed, including their use as prognostic indicators and predictors of response to systemic therapy.
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页数：11
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共 122 条
  • [1] Predictive value of apoptosis, proliferation, HER-2, and topoisomerase IIα for anthracycline chemotherapy in locally advanced breast cancer
    Arpino, G
    Ciocca, DR
    Weiss, H
    Allred, DC
    Daguerre, P
    Vargas-Roig, L
    Leuzzi, M
    Gago, F
    Elledge, R
    Mohsin, SK
    [J]. BREAST CANCER RESEARCH AND TREATMENT, 2005, 92 (01) : 69 - 75
  • [2] Studies of the potential utility of Ki67 as a predictive molecular marker of clinical response in primary breast cancer
    Assersohn, L
    Salter, J
    Powles, TJ
    A'hern, R
    Makris, A
    Gregory, RK
    Chang, J
    Dowsett, M
    [J]. BREAST CANCER RESEARCH AND TREATMENT, 2003, 82 (02) : 113 - 123
  • [3] CELL-PROLIFERATION KINETICS OF NORMAL AND TUMOR-TISSUE IN-VITRO - QUIESCENT REPRODUCTIVE CELLS AND THE CYCLING REPRODUCTIVE FRACTION
    BAKER, FL
    SANGER, LJ
    RODGERS, RW
    JABBOURY, K
    MANGINI, OR
    [J]. CELL PROLIFERATION, 1995, 28 (01) : 1 - 15
  • [4] Relationship between AgNOR proteins, Ki-67 antigen, p53 immunophenotype and differentiation markers in archival breast carcinomas
    Bànkfalvi, A
    Schmitz, K
    Mock, T
    Kemper, M
    Cubick, C
    Böcker, W
    [J]. ANALYTICAL CELLULAR PATHOLOGY, 1998, 17 (04): : 231 - 242
  • [5] Barbareschi M, 1999, Adv Clin Path, V3, P119
  • [6] PROLIFERATIVE INDEX IN BREAST-CARCINOMA DETERMINED INSITU BY KI67 IMMUNOSTAINING AND ITS RELATIONSHIP TO CLINICAL AND PATHOLOGICAL VARIABLES
    BARNARD, NJ
    HALL, PA
    LEMOINE, NR
    KADAR, N
    [J]. JOURNAL OF PATHOLOGY, 1987, 152 (04) : 287 - 295
  • [7] [18F]FLT-PET in oncology:: current status and opportunities
    Been, LB
    Suurmeijer, AJH
    Cobben, DCP
    Jager, PL
    Hoekstra, HJ
    Elsinga, PH
    [J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2004, 31 (12) : 1659 - 1672
  • [8] Imaging of primary breast cancer with 18F-fluorodeoxythymidine PET-CT reveals heterogeneity of proliferation throughout the tumour
    Beresford, M
    Sanghera, B
    Wong, WL
    Makris, A
    [J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2006, 33 (05) : 624 - 624
  • [9] BORGIANI L, 1994, EUR J HISTOCHEM, V38, P171
  • [10] KI67 IMMUNOSTAINING IN PRIMARY BREAST-CANCER - PATHOLOGICAL AND CLINICAL ASSOCIATIONS
    BOUZUBAR, N
    WALKER, KJ
    GRIFFITHS, K
    ELLIS, IO
    ELSTON, CW
    ROBERTSON, JFR
    BLAMEY, RW
    NICHOLSON, RI
    [J]. BRITISH JOURNAL OF CANCER, 1989, 59 (06) : 943 - 947
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