Measuring proliferation in breast cancer: practicalities and applications

被引：146
作者：
Beresford, Mark J. [1 ]
Wilson, George D.
Makris, Andreas
机构：
[1] Mt Vernon Canc Ctr, Northwood, Middx, England
[2] William Beaumont Hosp, Dept Radiat Oncol, Royal Oak, MI USA
来源：
BREAST CANCER RESEARCH | 2006年 / 8卷 / 06期
关键词：
D O I：
10.1186/bcr1618
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Various methods are available for the measurement of proliferation rates in tumours, including mitotic counts, estimation of the fraction of cells in S-phase of the cell cycle and immunohistochemistry of proliferation-associated antigens. The evidence, advantages and disadvantages for each of these methods along with other novel approaches is reviewed in relation to breast cancer. The potential clinical applications of proliferative indices are discussed, including their use as prognostic indicators and predictors of response to systemic therapy.
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页数：11
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