The acquisition, extinction and spontaneous recovery of Pavlovian drug conditioning induced by post-trial dopaminergic stimulation/inhibition

被引:12
作者
Santos, Breno Garone [1 ]
Carey, Robert J. [2 ,3 ]
Carrera, Marinete Pinheiro [1 ]
机构
[1] State Univ North Flutninense Darcy Rtheiro, Behav Pharmacol Grp, Lab Morphol & Pathol Anim Hlth, Ave Alberto Lamego 2000, BR-28013600 Campos Dos Goytacazes, RJ, Brazil
[2] VA Med Ctr, Res & Dev 151, 800 Irving Ave, Syracuse, NY 13210 USA
[3] SUNY Upstate Med Univ, 800 Irving Ave, Syracuse, NY USA
关键词
Trace-conditioning; Post-trial; Novel environment; Extinction; Spontaneous recovery; Apomorphine; REPEATED APOMORPHINE TREATMENTS; CONTEXT-SPECIFIC SENSITIZATION; BEHAVIORAL SENSITIZATION; COCAINE SENSITIZATION; ACCUMBENS DOPAMINE; LOCOMOTOR-ACTIVITY; RECEPTORS; RATS; MECHANISMS; EXPRESSION;
D O I
10.1016/j.pbb.2017.04.002
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
In contextual drug conditioning, the onset of the drug treatment is contiguous with the contextual cues. Evidence suggests that drug conditioning also can occur if there is a discontinuity between the onset of the drug effect and offset of the contextual cues. Here we examine whether post-trial contextual drug conditioning conforms to several Pavlovian conditioning tenets namely: acquisition, extinction and spontaneous recovery. Six groups of rats received apomorphine (0.05 or 2.0 mg/kg) and vehicle immediately or after a 15 min delay following a 5 min non-drug exposure to an open-field during three successive days (conditioning phase). The extinction phase occurred on days 4-8, in which all post-trial treatments were vehicle injections. After 2 days of non testing, the final test was performed. The results showed that on the first test day, the activity levels of the 6 groups were statistically equivalent. On test day 2, there were marked differences in activity levels selectively between the two immediate post-trial apomorphine treatment groups. The immediate low dose apomorphine group displayed a reduction in activity and the immediate high dose group an increase in activity relative to their day 1 levels. The activity levels of both vehicle groups and both apomorphine delay groups remained equivalent to their day 1 activity levels. On test day 3, the differences in activity levels between the two immediate post-trial apomorphine groups increased but the activity levels of the vehicle groups and the 15 min delay post-trial apomorphine groups remained unchanged. In the extinction phase, the conditioned activity differences between the two immediate post-trial apomorphine groups were gradually eliminated. During the final test, the activity differences between the immediate post-trial apomorphine groups were partially restored, indicative of spontaneous recovery. These findings are consistent with several basic elements of Pavlovian conditioning and are supportive of drug induced trace conditioning.
引用
收藏
页码:24 / 29
页数:6
相关论文
共 42 条
[1]  
Aghajanian G.K., 1973, FRONTIERS CATECHOLAM, P643
[2]  
[Anonymous], 1952, PSYCHOL LEARNING
[3]  
[Anonymous], 1928, Lectures on Conditioned Reflexes: Twenty-Five Years of Objective Study of the Higher Nervous Activity (Behavior) of Animals
[4]   Haloperidol conditioned catalepsy in rats: a possible role for D1-like receptors [J].
Banasikowski, Tomek J. ;
Beninger, Richard J. .
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2012, 15 (10) :1525-1534
[5]   PIMOZIDE BLOCKS ESTABLISHMENT BUT NOT EXPRESSION OF COCAINE-PRODUCED ENVIRONMENT-SPECIFIC CONDITIONING [J].
BENINGER, RJ ;
HERZ, RS .
LIFE SCIENCES, 1986, 38 (15) :1425-1431
[6]  
BENINGER RJ, 1991, MESOLIMBIC DOPAMINE SYSTEM : FROM MOTIVATION TO ACTION, P273
[7]   THE ROLE OF DOPAMINE IN LOCOMOTOR-ACTIVITY AND LEARNING [J].
BENINGER, RJ .
BRAIN RESEARCH REVIEWS, 1983, 6 (02) :173-196
[8]   Behavioral sensitization produced by a single administration of apomorphine: Implications for the role of Pavlovian conditioning in the mediation of context-specific sensitization [J].
Bloise, Enrrico ;
Carey, Robert J. ;
Carrera, Marinete Pinheiro .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2007, 86 (03) :449-457
[9]   CHRONIC COCAINE ADMINISTRATION SENSITIZES BEHAVIORAL BUT NOT NEUROENDOCRINE RESPONSES [J].
BOROWSKY, B ;
KUHN, CM .
BRAIN RESEARCH, 1991, 543 (02) :301-306
[10]   Behavioral sensitization to dopaminergic inhibitory and stimulatory effects induced by low vs. high dose apomorphine treatments: An unconventional dose and response reversal sensitization challenge test reveals sensitization mechanisms [J].
Braga, Priscila Quintanilha ;
Cruz Dias, Flavia Regina ;
Carey, Robert J. ;
Carrera, Marinete Pinheiro .
BEHAVIOURAL BRAIN RESEARCH, 2009, 204 (01) :169-174