Synthesis of novel phosphonated tritpodal ligands for actinides chelation therapy

被引：26

作者：

Chaleix, Vincent ^{[1
]}

Lecouvey, Marc ^{[1
]}

机构：

[1] Univ Paris 13, SMBH, UFR, BIOMOCETI,CNRS,UMR 7033, F-93017 Bobigny, France

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 04期

关键词：

bisphosphonate; reductive-amination; tripod; ligand; uranyl;

D O I：

10.1016/j.tetlet.2006.11.094

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient synthetic routes for preparation of a new family of aldehyde-bisphosphonate conjugates were presented. These compounds appeared as promising intermediates for incorporation of bisphosphonate moiety in various substrates under mild conditions. We report here a first application to the synthesis of a series of three phosphonated tripods designed for actinides chelation therapy. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：703 / 706

页数：4

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