Modulatory effects of diallyl sulfide against testosterone-induced oxidative stress in Swiss albino mice

被引:21
作者
Prasad, Sahdeo [1 ]
Kalra, Neetu [1 ]
Shukla, Yogeshwer [1 ]
机构
[1] Ind Toxicol Res Ctr, Div Environm Carcinogenesis, Lucknow 226001, Uttar Pradesh, India
关键词
oxidative stress; antioxidants; lipid peroxidation; diallyl sulfide; testosterone;
D O I
10.1111/j.1745-7262.2006.00201.x
中图分类号
R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
摘要
Aim: To investigate the protective effect of diallyl sulfide (DAS), a constituent of garlic, against testosterone-induced oxidative stress in male Swiss albino mice. Methods: The animals were given low (250 mg/animal) and high dose (500 mg/animal) of DAS in corn oil for 7 days along with testosterone (5 mg/kg body weight, i.p.). At the end of the study period, the prostate and the liver were dissected to determine various antioxidant enzyme levels (catalase, superoxide dismutase, glutathione reductase, glutathione-s-transferase) and lipid peroxidation. Results: In testosterone treated mice, depleted antioxidant enzyme level was accompanied with enhancement in lipid peroxidation in prostate and liver. DAS significantly restored the testosterone-induced antioxidant enzymes and lipid peroxidation in the both organs. These changes appear to be mediated by the antioxidant-enhancing effects of DAS. Conclusion: The results of the present study suggest that DAS is effective in exerting antioxidant effects by inhibiting testosterone-induced oxidative stress and might be helpful in preventing prostate cancer.
引用
收藏
页码:719 / 723
页数:5
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