Prenatal hypoxia predisposes vascular functional and structural changes associated with oxidative stress damage and depressive behavior in adult offspring male rats

被引：7

作者：

Goncalves da Silva, Thaina Ferraz ^{[1
]}

de Bem, Graziele Freitas ^{[1
]}

da Costa, Cristiane Aguiar ^{[1
]}

Santos, Izabelle Barcellos ^{[1
]}

Soares, Ricardo de Andrade ^{[1
]}

Ognibene, Dayane Teixeira ^{[1
]}

Rito-Costa, Fernanda ^{[1
]}

Cavalheira, Mariana Alencar ^{[1
]}

Conceicao, Sabrina Pereira ^{[1
]}

Ferraz, Marcos Rochedo ^{[1
]}

Resende, Angela Castro ^{[1
]}

机构：

[1] Univ Estado Rio De Janeiro, Inst Biol, Dept Pharmacol, Av 28 Setembro 87, BR-20551030 Rio De Janeiro, RJ, Brazil

来源：

PHYSIOLOGY & BEHAVIOR | 2021年 / 230卷

关键词：

Hypoxia-ischemia; Depression; Vascular dysfunction; Oxidative stress damage; NITRIC-OXIDE; FETAL ORIGINS; SMOOTH-MUSCLE; PLASMA-LEVELS; L-ARGININE; DYSFUNCTION; BRAIN; PREGNANCY; ISCHEMIA; DISEASE;

D O I：

10.1016/j.physbeh.2020.113293

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Intrauterine hypoxia-ischemia (HI) provides a strong stimulus for a developmental origin of both the central nervous system and cardiovascular diseases. This study aimed to investigate vascular functional and structural changes, oxidative stress damage, and behavioral alterations in adult male offspring submitted to HI during pregnancy. The pregnant Wistar rats had a uterine artery clamped for 45 min on the 18th gestational day, submitting the offspring to hypoxic-ischemic conditions. The Sham group passed to the same surgical procedure as the HI rats, without occlusion of the maternal uterine artery, and the controls consisted of non-manipulated healthy animals. After weaning, the male pups were divided into three groups: control, sham, and HI, according to the maternal procedure. At postnatal day 90 (P90), the adult male offspring performed the open field and forced swim tests. In P119, the rats had their blood pressure checked and were euthanized. Prenatal HI induced a depressive behavior in adult male offspring associated with a reduced vasodilator response to acetylcholine in perfused mesenteric arterial bed, and reduced superoxide dismutase and glutathione peroxidase activities in the aorta compared to control and sham groups. Prenatal HI also increased the vasoconstrictor response to norepinephrine, the media thickness, collagen deposition, and the oxidative damage in the aorta from adult male offspring compared to control and sham groups. Our results suggest an association among prenatal HI and adult vascular structural and functional changes, oxidative stress damage, and depressive behavior.

引用

页数：9

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