Serum levels of IGF-I, IGFBP-3 and colorectal cancer risk: results from the EPIC cohort, plus a meta-analysis of prospective studies

被引：186

作者：

Rinaldi, Sabina ^{[2
]}

Cleveland, Rebecca ^{[3
]}

Norat, Teresa ^{[4
]}

Biessy, Carine ^{[2
]}

Rohrmann, Sabine ^{[1
]}

Linseisen, Jakob ^{[1
]}

Boeing, Heiner ^{[5
]}

Pischon, Tobias ^{[5
]}

Panico, Salvatore ^{[6
]}

Agnoli, Claudia ^{[7
]}

Palli, Domenico ^{[8
]}

Tumino, Rosario ^{[9
]}

Vineis, Paolo ^{[4
,10
]}

Peeters, Petra H. M. ^{[11
]}

van Gils, Carla H. ^{[11
]}

Bueno-de-Mesquita, Bas H. ^{[12
]}

Vrieling, Alina ^{[12
]}

Allen, Naomi E. ^{[13
]}

Roddam, Andrew ^{[13
]}

Bingham, Sheila ^{[14
]}

Khaw, Kay-Tee ^{[15
]}

Manjer, Jonas ^{[16
]}

Borgquist, Signe ^{[17
]}

Dumeaux, Vanessa ^{[18
]}

Gram, Inger Torhild ^{[18
]}

Lund, Eiliv ^{[18
]}

Trichopoulou, Antonia ^{[19
]}

Makrygiannis, Georgios

Benetou, Vassiliki

Molina, Esther ^{[20
]}

Donate Suarez, Ignacio ^{[21
]}

Barricarte Gurrea, Aurelio ^{[22
]}

Gonzalez, Carlos A. ^{[23
]}

Tormo, Maria-Jose ^{[24
]}

Altzibar, Jone M.

Olsen, Anja ^{[25
]}

Tjonneland, Anne ^{[25
]}

Gronbaek, Henning ^{[26
]}

Overvad, Kim ^{[27
]}

Clavel-Chapelon, Francoise ^{[28
]}

Boutron-Ruault, Marie-Christine ^{[28
]}

Morois, Sophie ^{[28
]}

Slimani, Nadia ^{[2
]}

Boffetta, Paolo ^{[2
]}

Jenab, Mazda ^{[2
]}

Riboli, Elio ^{[4
]}

Kaaks, Rudolf ^{[1
]}

机构：

[1] German Canc Res Ctr, Div Canc Epidemiol, D-69120 Heidelberg, Germany

[2] Int Agcy Res Canc, F-69372 Lyon, France

[3] Univ N Carolina, Dept Nutr, Chapel Hill, NC USA

[4] Univ London Imperial Coll Sci Technol & Med, Publ Hlth & Primary Care Fac Med, Div Epidemiol, London, England

[5] German Inst Human Nutr, Dept Epidemiol, Potsdam, Germany

[6] Univ Naples Federico II, Dipartimento Med Clin & Sperimentale, Naples, Italy

[7] Fdn IRCCS, Ist Nazl Tumori, Nutrit Epidemiol Unit, Dept Prevent & Predict Med, Milan, Italy

[8] Canc Res & Prevent Inst ISPO, Mol & Nutrit Epidemiol Unit, Florence, Italy

[9] Azienda Osped CIVILE MP AREZZO, Canc Registry, Ragusa, Italy

[10] Fdn ISI, Turin, Italy

[11] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[12] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[13] Univ Oxford, Epidemiol Unit, Oxford, England

[14] Univ Cambridge, MRC, Ctr Nutr & Canc, Cambridge, England

[15] Univ Cambridge, Sch Clin Med, Cambridge, England

[16] Malmo Univ Hosp, Dept Surg, Malmo, Sweden

[17] Malmo Univ Hosp, Div Pathol, Dept Lab Med, Malmo, Sweden

[18] Univ Tromso, Inst Community Med, N-9001 Tromso, Norway

[19] Univ Athens, Sch Med, Greece & Hellen Hlth Fdn, Dept Hyg & Epidemiol, GR-10679 Athens, Greece

[20] Andalusian Sch Publ Hlth, Granada, Spain

[21] Hlth & Hlth Care Serv Council, Publ Hlth Directorate, Asturias, Spain

[22] Publ Hlth Inst Navarra, Pamplona, Spain

[23] Catalan Inst Oncol ICO, Unit Nutr Environm & Canc, Canc Epidemiol Res Programme, Barcelona, Spain

[24] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[25] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[26] Aarhus Univ Hosp, Med Dept 5, Aarhus, Denmark

[27] Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg, Denmark

[28] Univ Paris Sud, Inst Cancerol Gustave Roussy, ERI 20, INSERM,IFR 69, Villejuif, France

来源：

INTERNATIONAL JOURNAL OF CANCER | 2010年 / 126卷 / 07期

基金：

英国医学研究理事会;

关键词：

insulin-like growth factor-I (IGF-I); colorectal neoplasms; nested case control study; European Prospective Investigation into Cancer (EPIC); meta-analysis; GROWTH-FACTOR-I; BINDING PROTEIN-3; FACTOR SYSTEM; FACTOR (IGF)-I; C-PEPTIDE; FACTOR BINDING-PROTEIN-3; DIETARY INTERVENTION; CIRCULATING LEVELS; EUROPEAN WOMEN; BREAST-CANCER;

D O I：

10.1002/ijc.24927

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Several prospective studies have shown a moderate positive association between increasing circulating insulin-like growth factor-I (IGF-I) levels and colorectal cancer risk. However, the associations were often statistically nonsignificant, and the relationship of cancer risk with IGF-I's major binding protein, IGFBP-3, showed major discrepancies between studies. We investigated the association of colorectal cancer risk with serum IGF-I, total and intact IGFBP-3, in a case-control study nested within the EPIC cohort (1,121 cases of colorectal cancer and 1,121 matched controls). Conditional logistic regression was used to adjust for possible confounders. Our present study results were combined in a meta-analysis with those from 9 previous prospective studies to examine the overall evidence for a relationship of prediagnostic serum IGF-I with colorectal cancer risk. In the EPIC study, serum concentrations of IGF-I and IGFBP-3 showed no associations with risk of colorectal cancer overall. Only in subgroup analyses did our study show moderate positive associations of IGF-I levels with risk, either among younger participants only (and only for colon cancer) or among participants whose milk intakes were in the lowest tertile of the population distribution (RR for an increase of 100 ng/ml = 1.43 [95% CI = 1.13-1.93]). Nevertheless, in the meta-analysis a modest positive association remained between serum IGF-I and colorectal cancer risk overall (RR = 1.07 [1.01-1.14] for 1 standard deviation increase in IGF-I). Overall, data from our present study and previous prospective studies combined indicate a relatively modest association of colorectal cancer risk with serum IGF-I.

引用

页码：1702 / 1715

页数：14

共 56 条

[21] Energy balance and cancer: the role of insulin and insulin-like growth factor-I [J].

Kaaks, R ;

Lukanova, A .

PROCEEDINGS OF THE NUTRITION SOCIETY, 2001, 60 (01) :91-106

[22] Serum C-peptide, insulin-like growth factor (IGF)-I, IGF-binding proteins, and colorectal cancer risk in women [J].

Kaaks, R ;

Toniolo, P ;

Akhmedkhanov, A ;

Lukanova, A ;

Biessy, C ;

Dechaud, H ;

Rinaldi, S ;

Zeleniuch-Jacquotte, A ;

Shore, RE ;

Riboli, E .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2000, 92 (19) :1592-1600

[23] Serum sex steroids in premenopausal women and breast cancer risk within the European prospective investigation into cancer and nutrition (EPIC) [J].

Kaaks, R ;

Berrino, F ;

Key, T ;

Rinaldi, S ;

Dossus, L ;

Biessy, C ;

Secreto, G ;

Amiano, P ;

Bingham, S ;

Boeing, H ;

de Mesquita, HBB ;

Chang-Claude, J ;

Clavel-Chapelon, FO ;

Fournier, AS ;

van Gils, CH ;

Gonzalez, CA ;

Gurrea, AB ;

Critselis, E ;

Khaw, KT ;

Krogh, V ;

Lahmann, PH ;

Nagel, G ;

Olsen, A ;

Onland-Moret, NC ;

Overvad, K ;

Palli, D ;

Panico, S ;

Peeters, P ;

Quirós, JR ;

Roddam, A ;

Thiebaut, A ;

Tjonneland, A ;

Chirlaque, MD ;

Trichopoulou, A ;

Trichopoulos, D ;

Tumino, R ;

Vineis, P ;

Norat, T ;

Ferrari, P ;

Slimani, N ;

Riboli, E .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2005, 97 (10) :755-765

[24] Effects of dietary intervention on IGF-I and IGF-binding proteins, and related alterations in sex steroid metabolism: the Diet and Androgens (DIANA) Randomised Trial [J].

Kaaks, R ;

Bellati, C ;

Venturelli, E ;

Rinaldi, S ;

Secreto, G ;

Biessy, C ;

Pala, V ;

Sieri, S ;

Berrino, F .

EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2003, 57 (09) :1079-1088

[25]

Kaaks R, 2001, CANCER EPIDEM BIOMAR, V10, P1103

[26] INSULIN-LIKE GROWTH FACTOR-I COMPARISONS IN HEALTHY TWIN CHILDREN [J].

KAO, PC ;

MATHENY, AP ;

LANG, CA .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1994, 78 (02) :310-312

[27] Dietary calcium, phosphorus, vitamin D, dairy products and the risk of colorectal adenoma and cancer among French women of the E3N-EPIC prospective study [J].

Kesse, E ;

Boutron-Ruault, MC ;

Norat, T ;

Riboli, E ;

Clavel-Chapelon, F .

INTERNATIONAL JOURNAL OF CANCER, 2005, 117 (01) :137-144

[28] The effects of insulin-like growth factors on tumorigenesis and neoplastic growth [J].

Khandwala, HM ;

McCutcheon, IE ;

Flyvbjerg, A ;

Friend, KE .

ENDOCRINE REVIEWS, 2000, 21 (03) :215-244

[29] The insulin-like growth factor system and cancer [J].

LeRoith, D ;

Roberts, CT .

CANCER LETTERS, 2003, 195 (02) :127-137

[30] Prediagnostic levels of C-peptide, IGF-I, IGFBP-1,-2 and-3 [J].

Lukanova, A ;

Zeleniuch-Jacquotte, A ;

Lundin, E ;

Michel, A ;

Arslan, AA ;

Rinaldi, S ;

Muti, P ;

Lenner, P ;

Koenig, KL ;

Biessy, C ;

Krogh, V ;

Riboli, E ;

Shore, RE ;

Stattin, P ;

Berrino, F ;

Hallmans, C ;

Toniolo, P ;

Kaaks, R .

INTERNATIONAL JOURNAL OF CANCER, 2004, 108 (02) :262-268

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