System-Pharmacology Dissection of Traditional Chinese herbs SINI Decoction for Treatment of Cardiovascular Diseases

被引:11
作者
Shu, Zhiming [1 ]
Wu, Tiantian [1 ]
Shahen, Mohamed [1 ,2 ]
Guo, Zihu [1 ]
Shu, Jia [1 ]
Wang, He [1 ]
Shar, Akhtar H. [1 ]
Farag, Mayada R. [3 ]
Alagawany, Mahmoud [4 ]
Abd El-Hack, Mohamed E. [4 ]
Liu, Chaobin [5 ]
机构
[1] Northwest A&F Univ, Coll Life Sci, Yangling 712100, Shaanxi, Peoples R China
[2] Tanta Univ, Fac Sci, Zool Dept, Tanta 31527, Egypt
[3] Zagazig Univ, Vet Med Fac, Forens Med & Toxicol Dept, Zagazig 44511, Egypt
[4] Zagazig Univ, Dept Poultry, Fac Agr, Zagazig 44511, Egypt
[5] Northwest A&F Univ, Coll Forestry, Yangling 712100, Shaanxi, Peoples R China
来源
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS | 2019年 / 91卷 / 03期
基金
中国国家自然科学基金;
关键词
systems pharmacology; SINI Decoction; Cardiovascular Diseases; molecular mechanisms; traditional Chinese herbs; BLOOD-PRESSURE; MOLECULAR-MECHANISMS; GENE POLYMORPHISMS; RECEPTOR; INHIBITION; PROTECTION; ESTROGEN; PATHWAY; ALPHA; CONSTITUENTS;
D O I
10.1590/0001-3765201920180424
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Cardiovascular diseases (CVDs) are leading causes of death in the world, owing to noticeable incidence and mortality. Traditional Chinese Medicine (TCM) SINI Decoction (SND) is used to prevent and treat CVDs, which has attracted extensive attention for its moderate and little side effects. However, the involved molecular mechanisms are exceedingly complicated and remain unclear. Systems pharmacology, as a novel approach that integrates systems biology and pharmacology plays a significant role in investigating the molecular mechanism of TCM. In systems pharmacology approach, we use to systematically uncover the mechanisms of action in Chinese medicinal formula SND as an effective treatment for CVDs, which mainly includes:1) molecular database building; 2) ADME evaluation; 3) target-fishing 4) network construction and analysis. The results show that 78 underlying valid ingredients and their corresponding 71 direct targets of SND were obtained. And SND take part in cardiomyocyte protection, blood pressure regulation, and lipid regulation module in treatment of CVDs by cooperative way. Systems pharmacology as an emerging field that investigates the molecular mechanisms of TCM through pharmacokinetic evaluation target prediction, and pathway analysis, which will facilitate the development of traditional Chinese herbs in modern medicine.
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页数:16
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