New sol-gel-derived magnetic bioactive glass-ceramics containing superparamagnetic hematite nanocrystals for hyperthermia application

被引:38
作者
Borges, Roger [1 ]
Mendonca-Ferreira, Leticie [1 ]
Rettori, Carlos [1 ,2 ]
Pereira, Isis S. O. [1 ]
Baino, Francesco [3 ]
Marchi, Juliana [1 ]
机构
[1] Univ Fed ABC, Ctr Ciencias Nat & Humans, Ave Estados 5001 Bangu, BR-08210180 Santo Andre, SP, Brazil
[2] Univ Estadual Campinas, Inst Fis Gleb Wataghin, Rua Sergio Buarque Holanda 777 Cidade Univ, BR-13083859 Campinas, SP, Brazil
[3] Politecn Torino, Dept Appl Sci & Technol, Corso Duca Abruzzi 24, I-10129 Turin, Italy
来源
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2021年 / 120卷
基金
巴西圣保罗研究基金会;
关键词
Bioactive glass-ceramic; Superparamagnetism; Hyperthermia; Sol-gel; Hematite;
D O I
10.1016/j.msec.2020.111692
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Although the three main phases of iron oxide - hematite, maghemite, and magnetite - exhibit superparamagnetic properties at the nanoscale, only maghemite and magnetite phases have been explored in magnetic bioactive glass-ceramics aimed at applications in cancer treatment by hyperthermia. In this work, it is reported for the first time the superparamagnetic properties of hematite nanocrystals grown in a 58S bioactive glass matrix derived from sol-gel synthesis. The glass-ceramics are based on the (100-x)(58SiO(2)-33CaO-9P(2)O(5))-xFe(2)O(3) system (x = 10, 20 and 30 wt%). A thermal treatment leads to the growth of hematite (alpha-Fe2O3) nanocrystals, conferring superparamagnetic properties to the glass-ceramics, which is enough to produce heat under an external alternating magnetic field. Besides, the crystallization does not inhibit materials bioactivity, evidenced by the formation of calcium phosphate onto the glass-ceramic surface upon soaking in simulated body fluid. Moreover, their cytotoxicity is similar to other magnetic bioactive glass-ceramics reported in the literature. Finally, these results suggest that hematite nanocrystals' superparamagnetic properties may be explored in multifunctional glass-ceramics applied in bone cancer treatment by hyperthermia allied to bone regeneration.
引用
收藏
页数:12
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