Survival analysis of immune-related lncRNA in low-grade glioma

被引：46

作者：

Li, Xiaozhi ^{[1
]}

Meng, Yutong ^{[2
]}

机构：

[1] China Med Univ, Shengjing Hosp, Dept Neurosurg, Shenyang, Liaoning, Peoples R China

[2] China Med Univ, Dept Stomatol, Shengjing Hosp, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R China

来源：

BMC CANCER | 2019年 / 19卷 / 01期

关键词：

Low-grade glioma; lncRNA; Immune; Prognosis; LONG NONCODING RNAS; PROSTATE-CANCER; BIOMARKERS; BLOCKADE; CELLS;

D O I：

10.1186/s12885-019-6032-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Low-grade glioma is grade I-II glioma. Immunotherapy is a promising way of tumor killing. Research on immune molecular mechanisms in low-grade gliomas and discovery of new immune checkpoints for low-grade gliomas are of great importance. Methods Gene sequencing data and clinical data of low-grade glioma were downloaded from TCGA database. Prognosis related lncRNAs were identified by Cox regression and their possible functions were found by gene enrichment set analysis. Results A total of 529 low-grade glioma samples and 5 non-tumor brain tissue samples are obtained from the TCGA database. Two hundred forty-seven immune-associated lncRNAs are screened. Cox regression showed that 16 immune-related lncRNAs are associated with low-grade glioma prognosis, and 7 lncRNAs are independent risk factors. Gene set enrichment analysis suggests that these molecules are enriched in extracellular region, sequence-specific DNA binding, neuropeptide signaling pathway, transcriptional misregulation in cancer, cytokine-cytokine receptor interaction, protein digestion and absorption, chemokine signaling pathway, etc. Conclusion The identification of immune-related lncRNA may provide new targets for the research of the molecular mechanisms and treatment of low-grade glioma.

引用

页数：6

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