Fortification of the whey protein isolate antioxidant and antidiabetic activity with fraction rich in phenolic compounds obtained from Stevia rebaudiana (Bert.). Bertoni leaves

被引：21

作者：

Milani, Paula Gimenez ^{[1
]}

Formigoni, Maysa ^{[1
]}

Lima, Yago Carvalho ^{[2
]}

Piovan, Silvano ^{[2
]}

Ledesma Peixoto, Giuliana Maria ^{[2
]}

Camparsi, Daiane Montoia ^{[4
]}

da Silva Rodrigues, Willian do Nascimento ^{[4
]}

Pereira da Silva, Jordana Quaglia ^{[5
]}

Avincola, Alexandre da Silva ^{[3
]}

Pilau, Eduardo Jorge ^{[3
]}

Mareze da Costa, Cecilia Edna ^{[2
]}

da Costa, Silvio Claudio ^{[6
]}

机构：

[1] Univ Estadual Maringa, Programa Posgrad Ciencia Alimentos, Ave Colombo,5790 Jardim Univ, BR-87020900 Maringa, Parana, Brazil

[2] Univ Estadual Maringa, Programa Posgrad Ciencias Fisiol, Dept Ciencias Fisiol, Ave Colombo,5790 Jardim Univ, BR-87020900 Maringa, Parana, Brazil

[3] Univ Estadual Maringa, Dept Quim, Ave Colombo,5790 Jardim Univ, BR-87020900 Maringa, Parana, Brazil

[4] Univ Estadual Maringa, Dept Biol, Ave Colombo,5790 Jardim Univ, BR-87020900 Maringa, Parana, Brazil

[5] Univ Estadual Maringa, Dept Bioquim, Ave Colombo,5790 Jardim Univ, BR-87020900 Maringa, Parana, Brazil

[6] Univ Estadual Maringa, Dept Bioquim, Programa Posgrad Ciencia Alimentos, Ave Colombo,5790 Jardim Univ, BR-87020900 Maringa, Parana, Brazil

来源：

JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE | 2017年 / 54卷 / 07期

关键词：

Whey protein isolate; Antioxidant fraction of Stevia rebaudiana; Phenolic compounds; Flavonoids; Diabetes mellitus; STREPTOZOTOCIN; GLUCOSE; STEVIOSIDE; EXTRACT; CELLS;

D O I：

10.1007/s13197-017-2638-0

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

A stevia fraction (ASF) free of steviol glycosides was extracted from Stevia rebaudiana leaves (Stevia UEM-13). ASF essentially constitutes phenolic compounds (52.42%), which were identified by liquid chromatography tandem mass spectrometry (LC-MS/MS) as caffeic acid, quercetin-3-o-glycoside, cyanidin-3-glucoside, kaempferol, quercetin, apigenin, rozmarinic acid, chlorogenic acid and dicaffeoylquinic acid. ASF was used as a multi-functional source of phenolic compounds to fortify the whey protein isolate (WPI) obtained by membrane separation. WPI fortified with 0.2% ASF showed an 80% increase in its antioxidant activity and more pronounced antidiabetic effects than the unfortified WPI, mainly in the glycemic control of diabetic animals induced by streptozotocin. The in vitro and in vivo antioxidant effects of ASF may enhance the effects of WPI. Indeed, this pioneering study revealed that ASF can be used to enrich the antioxidant and antidiabetic properties of WPI.

引用

页码：2020 / 2029

页数：10

共 17 条

[1] Fortification of the whey protein isolate antioxidant and antidiabetic activity with fraction rich in phenolic compounds obtained from Stevia rebaudiana (Bert.). Bertoni leaves
Paula Gimenez Milani
Maysa Formigoni
Yago Carvalho Lima
Silvano Piovan
Giuliana Maria Ledesma Peixoto
Daiane Montoia Camparsi
Willian do Nascimento da Silva Rodrigues
Jordana Quaglia Pereira da Silva
Alexandre da Silva Avincola
Eduardo Jorge Pilau
Cecília Edna Mareze da Costa
Silvio Cláudio da Costa
Journal of Food Science and Technology, 2017, 54 : 2020 - 2029
[2] Antidiabetic activity of medium-polar extract from the leaves of Stevia rebaudiana Bert. (Bertoni) on alloxan-induced diabetic rats
Misra, Himanshu
Soni, Manish
Silawat, Narendra
Mehta, Darshana
Mehta, B. K.
Jain, D. C.
JOURNAL OF PHARMACY AND BIOALLIED SCIENCES, 2011, 3 (02): : 242 - 248
[3] In vitro antioxidant activity and total phenolic content of ethanolic leaf extract of Stevia rebaudiana Bert.
Shukla, Shruti
Mehta, Archana
Bajpai, Vivek K.
Shukla, Savita
FOOD AND CHEMICAL TOXICOLOGY, 2009, 47 (09) : 2338 - 2343
[4] Whey protein sweetened with Stevia rebaudiana Bertoni (Bert.) increases mitochondrial biogenesis markers in the skeletal muscle of resistance-trained rats
Lima, Yago Carvalho
Kurauti, Mirian Ayumi
Alves, Gabriel da Fonseca
Ferezini, Jonathan
Piovan, Silvano
Malta, Ananda
Alves de Almeida, Fernanda Losi
Gomes, Rodrigo Mello
de Freitas Mathias, Paulo Cezar
Milani, Paula Gimenez
da Costa, Silvio Cludio
Mareze-Costa, Cecilia Edna
NUTRITION & METABOLISM, 2019, 16 (01)
[5] Whey protein sweetened with Stevia rebaudiana Bertoni (Bert.) increases mitochondrial biogenesis markers in the skeletal muscle of resistance-trained rats
Yago Carvalho Lima
Mirian Ayumi Kurauti
Gabriel da Fonseca Alves
Jonathan Ferezini
Silvano Piovan
Ananda Malta
Fernanda Losi Alves de Almeida
Rodrigo Mello Gomes
Paulo Cezar de Freitas Mathias
Paula Gimenez Milani
Silvio Cláudio da Costa
Cecilia Edna Mareze-Costa
Nutrition & Metabolism, 16
[6] Optimization of concentration of stevia leaves (Stevia rebaudiana Bert.) and black tea: study on phytochemical composition and antioxidant activity of mixed stevia-black tea solution
Budianta, T. D. W.
Utomo, A. R.
Raharjo, S. J.
INTERNATIONAL CONFERENCE ON INNOVATION IN TECHNOLOGY AND MANAGEMENT FOR SUSTAINABLE AGROINDUSTRY (ITAMSA 2019), 2020, 472
[7] Microencapsulated antioxidant stevia fraction fortifies whey protein and enhances its antidiabetic activity
Cynthia Letícia S. Cabeça
Natani Caroline Nogueira
Maria Rosa T. Zorzenon
Antonio Sergio Dacome
Grasiele Scaramal Madrona
Cecília Edna Mareze da Costa
Silvio Claudio da Costa
Paula Gimenez Milani
Journal of Food Science and Technology, 2023, 60 : 2275 - 2285
[8] Microencapsulated antioxidant stevia fraction fortifies whey protein and enhances its antidiabetic activity
Cabeca, Cynthia Leticia S.
Nogueira, Natani Caroline
Zorzenon, Maria Rosa T.
Dacome, Antonio Sergio
Madrona, Grasiele Scaramal
da Costa, Cecilia Edna Mareze
da Costa, Silvio Claudio
Milani, Paula Gimenez
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE, 2023, 60 (08): : 2275 - 2285
[9] Evaluation of new extraction approaches to obtain phenolic compound-rich extracts from Stevia rebaudiana Bertoni leaves
Ciulu, Marco
Quirantes-Pine, Rosa
Spano, Nadia
Sanna, Gavino
Borras-Linares, Isabel
Segura-Carretero, Antonio
INDUSTRIAL CROPS AND PRODUCTS, 2017, 108 : 106 - 112
[10] Evaluating the potential of cell disruption technologies for green selective extraction of antioxidant compounds from Stevia rebaudiana Bertoni leaves
Barba, Francisco J.
Grimi, Nabil
Vorobiev, Eugene
JOURNAL OF FOOD ENGINEERING, 2015, 149 : 222 - 228

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