Solid-phase synthesis of linked heterocycles from a selenopolystyrene resin

被引：16
作者：
Huang, Xian
Wang, Yu-Guang
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310028, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China
来源：
JOURNAL OF COMBINATORIAL CHEMISTRY | 2007年 / 9卷 / 01期
关键词：
D O I：
10.1021/cc0600775
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A linked heterocycle library of isoxazoles, 1,2,3-triazoles, bicyclo[2.2.1]hepta-2,5-diene or 4-methylcyclohexa-1,3-diene and 1,2,4-oxadiazoles was prepared by solid-phase organic synthesis. Key steps on resin-bound selenium were electrophilic additions; 1,3-dipolar cycloaddition; Porco's two-step, one-pot condensation of amidoxime and carboxylate; and Diels-Alder reaction.
引用
收藏
页码：121 / 130
页数：10
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