Gold-Catalyzed Suzuki Coupling of ortho-Substituted Hindered Aryl Substrates

被引：27

作者：

Dwadnia, Nejib ^{[1
]}

Roger, Julien ^{[1
]}

Pirio, Nadine ^{[1
]}

Cattey, Helene ^{[1
]}

Ben Salem, Ridha ^{[2
]}

Hierso, Jean-Cyrille ^{[1
,3
]}

机构：

[1] Univ Bourgogne, UBFC, CNRS, Inst Chim Mol,UMR 6302, 9 Ave Alain Savary, F-21078 Dijon, France

[2] Univ Sfax, Fac Sci, Lab Chim Organ Phys UR11ES74, Sfax 3038, Tunisia

[3] IUF, 103 Blvd St Michel, F-75005 Paris, France

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2017年 / 12卷 / 04期

关键词：

COMPLEXES; GOLD(III); NANOPARTICLES; REACTIVITY; BROMIDES; HALIDES; ACIDS;

D O I：

10.1002/asia.201601583

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A method that allows hindered ortho-substituted aryl iodides to be efficiently coupled to phenylboronic acid using a gold-catalyzed C-C bond formation is presented. The use of a molecularly-defined dinuclear gold chloride catalytic precursor that is stabilized by a new tetradentate (N,N')-diamino-(P,P')-diphosphino ferrocene hybrid ligand in a Suzuki-type reaction is described for the first time. Electron-rich isopropyl groups on phosphorus were found essen-tial for a superior activity, while the performances of a set of analogous gold dinuclear complexes that were fully characterized by multinuclear NMR spectroscopy and XRD analysis, were investigated. Therefore, arylation of para and orthosubstituted iodoarenes bearing electron-rich, electron-poor functional groups, and even hindered polycyclic aromatic compounds is described.

引用

页码：459 / 464

页数：6

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