Multidrug resistance protein expression of adult T-cell leukemia/lymphoma

被引：9
|
作者：
Yasunami, Takeshi
Wang, Yan-hua
Tsuji, Kazue
Takanashi, Minoko
Yamada, Yasuaki
Motoji, Toshiko [1 ]
机构：
[1] Tokyo Womens Med Univ, Dept Hematol, Tokyo, Japan
[2] Japanese Red Cross Tokyo Blood Ctr, Tech Dept, Tokyo, Japan
[3] Nagasaki Univ, Grad Sch Biomed Sci, Dept Lab Med, Nagasaki, Japan
来源：
LEUKEMIA RESEARCH | 2007年 / 31卷 / 04期
关键词：
adult T-cell leukemia/lymphoma; multidrug resistance protein (MDR); lung resistance-related protein (LRP); multidrug resistance-associated protein (MRP); P-glycoprotein (P-gp);
D O I：
10.1016/j.leukres.2006.10.012
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In adult T-cell leukemia/lymphoma (ATL), it is difficult to achieve remission and the reason for the resistance to chemotherapeutic agents may be linked to the presence of multidrug resistance (MDR) proteins. Lung resistance-related protein (LRP), multidrug resistance-associated protein and P-glycoprotein are three MDR proteins which we examined in ATL cells using multiparametric flow cytometry and real-time RT-PCR. LRP was highly expressed and suppressing LRP function increased doxorubicin accumulation in nuclei. This indicates LRP may be contributing to drug resistance in ATL patients, and the suppression of LRP function could be a new strategy for ATL treatment. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：465 / 470
页数：6
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