Multidrug resistance protein expression of adult T-cell leukemia/lymphoma

被引：9
|
作者：
Yasunami, Takeshi
Wang, Yan-hua
Tsuji, Kazue
Takanashi, Minoko
Yamada, Yasuaki
Motoji, Toshiko [1 ]
机构：
[1] Tokyo Womens Med Univ, Dept Hematol, Tokyo, Japan
[2] Japanese Red Cross Tokyo Blood Ctr, Tech Dept, Tokyo, Japan
[3] Nagasaki Univ, Grad Sch Biomed Sci, Dept Lab Med, Nagasaki, Japan
来源：
LEUKEMIA RESEARCH | 2007年 / 31卷 / 04期
关键词：
adult T-cell leukemia/lymphoma; multidrug resistance protein (MDR); lung resistance-related protein (LRP); multidrug resistance-associated protein (MRP); P-glycoprotein (P-gp);
D O I：
10.1016/j.leukres.2006.10.012
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In adult T-cell leukemia/lymphoma (ATL), it is difficult to achieve remission and the reason for the resistance to chemotherapeutic agents may be linked to the presence of multidrug resistance (MDR) proteins. Lung resistance-related protein (LRP), multidrug resistance-associated protein and P-glycoprotein are three MDR proteins which we examined in ATL cells using multiparametric flow cytometry and real-time RT-PCR. LRP was highly expressed and suppressing LRP function increased doxorubicin accumulation in nuclei. This indicates LRP may be contributing to drug resistance in ATL patients, and the suppression of LRP function could be a new strategy for ATL treatment. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：465 / 470
页数：6
相关论文
共 50 条
  • [1] Expression and phosphorylation status of retinoblastoma protein in adult T-cell leukemia/lymphoma
    Nakayama, K
    Yamada, Y
    Koji, T
    Hayashi, T
    Tomonaga, M
    Kamihira, S
    LEUKEMIA RESEARCH, 2000, 24 (04) : 299 - 305
  • [2] Adult T-cell leukemia/lymphoma
    Oliveira, Pedro Dantas
    Farre, Lourdes
    Bittencourt, Achilea Lisboa
    REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, 2016, 62 (07): : 691 - 700
  • [3] Adult T-cell leukemia/lymphoma
    Bittencourt, Achilea L.
    Farre, Lourdes
    ANAIS BRASILEIROS DE DERMATOLOGIA, 2008, 83 (04) : 351 - 359
  • [4] ADULT T-CELL LEUKEMIA LYMPHOMA IN AN ABORIGINE
    KIRKLAND, MA
    FRASCA, J
    BASTIAN, I
    AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE, 1991, 21 (05): : 739 - 741
  • [5] MULTIINSTITUTIONAL STUDY OF CUTANEOUS T-CELL LYMPHOMA AND ADULT T-CELL LEUKEMIA-LYMPHOMA
    NAGATANI, T
    MIYAGAWA, K
    BABA, N
    FUKAYA, T
    HAMADA, T
    HIRONE, T
    HISADOME, H
    HONBO, S
    HORI, Y
    IMAMURA, S
    INOUE, S
    ITO, M
    IWATSUKI, K
    JOHNO, M
    KOBAYASHI, H
    KUROKI, Y
    MIYAMOTO, H
    NAKAJIMA, H
    NAKAYAMA, J
    OKAWARA, A
    OGATA, K
    ONO, T
    SATO, Y
    TAKATA, M
    TAKEZAKI, S
    TASHIRO, M
    YAMAGUCHI, S
    YAMADA, M
    EUROPEAN JOURNAL OF DERMATOLOGY, 1994, 4 (04) : 299 - 303
  • [6] Adult T-Cell Leukemia/Lymphoma in Bahia, Brazil
    Bittencourt, Achilea L.
    Vieira, Maria da Gracas
    Brites, Carlos R.
    Farre, Lourdes
    Barbosa, Helenemarie S.
    AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2007, 128 (05) : 875 - 882
  • [7] New treatments for adult T-cell leukemia/lymphoma
    Epstein-Peterson, Zachary D.
    Gurumurthi, Ashwath
    Horwitz, Steven M.
    LEUKEMIA RESEARCH, 2025, 149
  • [8] Adult T-cell leukemia/lymphoma triggered by adalimumab
    Bittencourt, Achilea L.
    Oliveira, Pedro D.
    Bittencourt, Valeria G.
    Carvalho, Edgar M.
    Farre, Lourdes
    JOURNAL OF CLINICAL VIROLOGY, 2013, 58 (02) : 494 - 496
  • [9] Genetic alterations in adult T-cell leukemia/lymphoma
    Kogure, Yasunori
    Kataoka, Keisuke
    CANCER SCIENCE, 2017, 108 (09): : 1719 - 1725
  • [10] Primary adult T-cell leukemia/lymphoma of bone
    Hara, T
    Wakatsuki, S
    Ozaki, S
    Abe, M
    Kosaka, M
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 2004, 79 (02) : 157 - 160
12345